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Literature summary extracted from

  • Wang, T.P.; Kaplan, N.O.
    Kinases for the synthesis of coenzyme A and triphosphopyridine nucleotide (1954), J. Biol. Chem., 206, 311-325.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.1.24 cysteine activation Anas platyrhynchos
2.7.1.24 cysteine activation Columba sp.
2.7.1.24 cysteine requirement Anas platyrhynchos
2.7.1.24 cysteine requirement Columba sp.

General Stability

EC Number General Stability Organism
2.7.1.24 stable to repeated freeze-thawing cycles Columba sp.

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.24 additional information no inhibition by F- with or without phosphate, adenosine, 2-, 3- or 5-adenylic acids, ADP, NAD+, NADH, deamino-NAD+, adenosine diphosphate ribose Columba sp.

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.1.24 0.003
-
 dephospho-CoA pH 8.2, 37°C Columba sp.

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.1.24 mitochondrion
-
 Anas platyrhynchos 5739
-
2.7.1.24 mitochondrion
-
 Columba sp. 5739
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.1.24 Mg2+ requirement Anas platyrhynchos
2.7.1.24 Mg2+ requirement Columba sp.

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.24 Anas platyrhynchos
-
 duck
-
2.7.1.24 Columba sp.
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.1.24 4.5fold from liver acetone powder Columba sp.

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.24 liver
-
 Anas platyrhynchos
-
2.7.1.24 liver
-
 Columba sp.
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.7.1.24 additional information
-
-
 Columba sp.

Storage Stability

EC Number Storage Stability Organism
2.7.1.24 -15°C, partially purified preparation, at least 2 months Columba sp.

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.24 ATP + dephospho-CoA specific Anas platyrhynchos ADP + CoA
-
 ?
2.7.1.24 ATP + dephospho-CoA specific Columba sp. ADP + CoA
-
 ?
2.7.1.24 ATP + dephospho-CoA ITP or ADP are no substrates Anas platyrhynchos ADP + CoA
-
 ?
2.7.1.24 ATP + dephospho-CoA ITP or ADP are no substrates Columba sp. ADP + CoA
-
 ?
2.7.1.24 additional information assay method: arsenolysis of dephospho-CoA, formation of CoA Anas platyrhynchos ?
-
 ?
2.7.1.24 additional information assay method: arsenolysis of dephospho-CoA, formation of CoA Columba sp. ?
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.1.24 37
-
 assay at Anas platyrhynchos
2.7.1.24 37
-
 assay at Columba sp.

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.1.24 8.2
-
 assay at Columba sp.

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.1.24 ATP requirement Anas platyrhynchos
2.7.1.24 ATP requirement Columba sp.