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Literature summary extracted from

  • Ktori, C.; Shepherd, P.R.; O'Rourke, L.
    TNF-alpha and leptin activate the alpha-isoform of class II phosphoinositide 3-kinase (2003), Biochem. Biophys. Res. Commun., 306, 139-143.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.1.154 Insulin
-
 Mus musculus
2.7.1.154 leptin 4fold activation of class II isoform PI3K-C2beta by activation of the ERK pathway, no recruitment of tyrosine phosphorylated proteins to the isozyme, blockade of activation by MEK-inhibitor PD98059 Mus musculus
2.7.1.154 additional information TNFalpha and leptin stimulate the alpha-isoform of class II phosphoinositide 3-kinase Mus musculus
2.7.1.154 TNF-alpha 2.8fold activation of class II isoform PI3K-C2beta by activation of the ERK pathway, blockade of activation by MEK-inhibitor PD98059 Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.154 additional information Mus musculus TNFalpha and leptin stimulate the alpha-isoform of class II phosphoinositide 3-kinase ?
-
 ?
2.7.1.154 additional information Mus musculus the enzyme is regulated by intracellular signalling mechanisms ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.154 Mus musculus
-
 PI3KC2alpha
-
2.7.1.154 Mus musculus
-
 class II isoform PI3K-C2beta
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.154 J774.2 cell
-
 Mus musculus
-
2.7.1.154 J774.2 cell macrophage Mus musculus
-
2.7.1.154 macrophage cell culture Mus musculus
-
2.7.1.154 macrophage cell culture, cell line J774.2 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.154 ATP + 1-phosphatidyl-1D-myo-inositol preferred substrate of enzyme form PI3K-C2beta Mus musculus ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
-
 ?
2.7.1.154 additional information TNFalpha and leptin stimulate the alpha-isoform of class II phosphoinositide 3-kinase Mus musculus ?
-
 ?
2.7.1.154 additional information the enzyme is regulated by intracellular signalling mechanisms Mus musculus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.154 phosphoinositide 3-kinase
-
 Mus musculus
2.7.1.154 PI 3-kinase
-
 Mus musculus
2.7.1.154 PI3K
-
 Mus musculus