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Literature summary extracted from

  • Benovic, J.L.; Regan, J.W.; Matsui, H.; Mayor, F.; Cotecchia, S.; Leeb-Lundberg, L.M.F.; Caron, M.G.; Lefkowitz, R.J.
    Agonist-dependent phosphorylation of the alpha 2-adrenergic receptor by the beta-adrenergic receptor kinase (1987), J. Biol. Chem., 262, 17251-17253.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.15 (-)-Epinephrine requirement, agonist, alpha2-adrenergic receptor as substrate Bos taurus
2.7.11.15 isoproterenol requirement, beta-agonist, beta-adrenergic receptor as substrate Bos taurus
2.7.11.15 additional information alpha2-AR phosphorylation is not stimulated by isoproterenol Bos taurus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.15 alpha2-adrenergic antagonist co-incubation completely blocks phosphorylation of alpha2-adrenergic receptor Bos taurus
2.7.11.15 additional information alprenolol is no inhibitor with alpha2-adrenergic receptor as substrate Bos taurus
2.7.11.15 Yohimbine alpha2-adrenergic antagonist, co-incubation completely blocks phosphorylation of alpha2-adrenergic receptor Bos taurus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.15 Mg2+ requirement Bos taurus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.15 ATP + beta-adrenergic receptor Bos taurus desensitization of beta-adrenergic receptor ADP + phospho-beta-adrenergic receptor
-
?
2.7.11.15 ATP + beta-adrenergic receptor Bos taurus agonist-occupied form of the receptor ADP + phospho-beta-adrenergic receptor
-
?
2.7.11.15 additional information Bos taurus phosphorylates and regulates receptors coupled to either stimulation or inhibition of adenylate cyclase ?
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.15 Bos taurus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.11.15
-
Bos taurus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.15 brain cerebral cortex Bos taurus
-
2.7.11.15 cerebral cortex
-
Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.15 ATP + alpha2-adrenergic receptor dependent on agonist occupancy by (-)-epinephrine, equally effective as beta-adrenergic receptor, incorporation of 7-8 mol phosphate/mol receptor Bos taurus ADP + phospho-alpha2-adrenergic receptor
-
?
2.7.11.15 ATP + alpha2-adrenergic receptor from human platelets Bos taurus ADP + phospho-alpha2-adrenergic receptor
-
?
2.7.11.15 ATP + beta-adrenergic receptor incorporation of 7-8 mol phosphate/mol receptor Bos taurus ADP + phospho-beta-adrenergic receptor
-
?
2.7.11.15 ATP + beta-adrenergic receptor specifically phosphorylates the agonist-occupied form of the receptor Bos taurus ADP + phospho-beta-adrenergic receptor
-
?
2.7.11.15 ATP + beta-adrenergic receptor at a similar rate as alpha2-adrenergic receptor Bos taurus ADP + phospho-beta-adrenergic receptor
-
?
2.7.11.15 ATP + beta-adrenergic receptor beta-AR from hamster lung Bos taurus ADP + phospho-beta-adrenergic receptor
-
?
2.7.11.15 ATP + beta-adrenergic receptor desensitization of beta-adrenergic receptor Bos taurus ADP + phospho-beta-adrenergic receptor
-
?
2.7.11.15 ATP + beta-adrenergic receptor agonist-occupied form of the receptor Bos taurus ADP + phospho-beta-adrenergic receptor
-
?
2.7.11.15 ATP + rhodopsin beta-AR is a much better substrate than rhodopsin Bos taurus ADP + phosphorhodopsin
-
?
2.7.11.15 ATP + rhodopsin light-dependent, actual substrate: light-bleached rhodopsin Bos taurus ADP + phosphorhodopsin
-
?
2.7.11.15 ATP + rhodopsin incorporation of 0.15 mol phosphate/mol rhodopsin Bos taurus ADP + phosphorhodopsin
-
?
2.7.11.15 ATP + rhodopsin in form of bovine rod outer segments Bos taurus ADP + phosphorhodopsin
-
?
2.7.11.15 additional information not: alpha1-adrenergic receptor Bos taurus ?
-
?
2.7.11.15 additional information phosphorylates and regulates receptors coupled to either stimulation or inhibition of adenylate cyclase Bos taurus ?
-
?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.11.15 30
-
assay at Bos taurus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.11.15 7.5
-
assay at Bos taurus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.15 ATP
-
Bos taurus