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Literature summary extracted from

  • Hawley, S.A.; Selbert, M.A.; Goldstein, E.G.; Edelman, A.M.; Carling, D.; Hardie, D.G.
    5'-AMP activates the AMP-activated protein kinase cascade, and Ca2+/calmodulin activates the calmodulin-dependent protein kinase I cascade, via three independent mechanisms (1995), J. Biol. Chem., 270, 27186-27191.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.31 5'-AMP regulated by allosteric activation Rattus norvegicus
2.7.11.31 additional information activated by phosphorylation by upstream protein kinases AMPKK and CaMKIK Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.3 ATP + dephospho-[[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase] Rattus norvegicus bicyclic phosphorylation system, enzyme is believed to be involved in protecting cells against ATP depletion due to environmental stress by inactivating several key biosynthetic enzymes ADP + [[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase]
-
 ?
2.7.11.3 ATP + dephospho-[[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase] Rattus norvegicus phosphorylation activates EC 2.7.1.109 ADP + [[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase]
-
 ?
2.7.11.31 ATP + [hydroxymethylglutaryl-CoA reductase (NADPH)] Rattus norvegicus bicyclic phosphorylation system, enzyme is believed to be involved in protecting cells against ATP depletion due to environmental stress by inactivating several key biosynthetic enzymes ADP + [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.3 Rattus norvegicus
-
-
-
2.7.11.31 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.3 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.3 ATP + dephospho-[[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase]
-
 Rattus norvegicus ADP + [[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase]
-
 ?
2.7.11.3 ATP + dephospho-[[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase] bicyclic phosphorylation system, enzyme is believed to be involved in protecting cells against ATP depletion due to environmental stress by inactivating several key biosynthetic enzymes Rattus norvegicus ADP + [[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase]
-
 ?
2.7.11.3 ATP + dephospho-[[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase] phosphorylation activates EC 2.7.1.109 Rattus norvegicus ADP + [[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase]
-
 ?
2.7.11.31 ATP + [hydroxymethylglutaryl-CoA reductase (NADPH)]
-
 Rattus norvegicus ADP + [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate
-
 ?
2.7.11.31 ATP + [hydroxymethylglutaryl-CoA reductase (NADPH)] bicyclic phosphorylation system, enzyme is believed to be involved in protecting cells against ATP depletion due to environmental stress by inactivating several key biosynthetic enzymes Rattus norvegicus ADP + [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate
-
 ?