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Literature summary extracted from

  • Beg, Z.H.; Stonik, J.A.; Brewer, B.
    Human hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase: evidence for the regulation of enzymic activity by a bicyclic phosphorylation cascade (1984), Biochem. Biophys. Res. Commun., 119, 488-498.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.31 Reductase kinase kinase activation, i.e. EC 2.7.1.110, in the presence of MgATP2- Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.31 Protein phosphatase
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.11.3 microsome
-
 Homo sapiens
-
-
2.7.11.31 cytosol
-
 Homo sapiens 5829
-
2.7.11.31 microsome
-
 Homo sapiens
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.3 Mg2+ requirement, actual substrate: MgATP Homo sapiens
2.7.11.31 Mg2+ requirement, actual substrate: MgATP2- Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.3 ATP + dephospho-[[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase] Homo sapiens phosphorylation activates EC 2.7.1.109 ADP + [[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase]
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.3 Homo sapiens
-
-
-
2.7.11.31 Homo sapiens
-
 human
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.11.3 partial Homo sapiens
2.7.11.31 partial Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.3 liver
-
 Homo sapiens
-
2.7.11.31 liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.3 ATP + dephospho-[[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase]
-
 Homo sapiens ADP + [[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase]
-
 ?
2.7.11.3 ATP + dephospho-[[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase] phosphorylation activates EC 2.7.1.109 Homo sapiens ADP + [[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase]
-
 ?
2.7.11.31 ATP + [hydroxymethylglutaryl-CoA reductase (NADPH)]
-
 Homo sapiens ADP + [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.11.3 37
-
-
 Homo sapiens
2.7.11.31 30
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.11.3 7.4
-
 assay at Homo sapiens