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Literature summary extracted from

  • Beg, Z.H.; Stonik, J.A.; Brewer, B.
    In vivo modulation of rat liver 3-hydroxy-3-methylglutaryl-coenzyme A reductase, reductase kinase, and reductase kinase kinase by mevalonolactone (1984), Proc. Natl. Acad. Sci. USA, 81, 7293-7297.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.3 Mevalonolactone activation, in vitro and in vivo Rattus norvegicus
2.7.11.31 Reductase kinase kinase activation, i.e. EC 2.7.1.110, in the presence of MgATP2- Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.11.3 cytosol predominant Rattus norvegicus 5829
-
2.7.11.31 cytosol
-
Rattus norvegicus 5829
-
2.7.11.31 microsome
-
Rattus norvegicus
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.3 Mg2+ requirement, actual substrate: MgATP Rattus norvegicus
2.7.11.31 Mg2+ requirement, actual substrate: MgATP2- Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.3 ATP + dephospho-[[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase] Rattus norvegicus phosphorylation activates EC 2.7.1.109 ADP + [[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase]
-
?
2.7.11.3 ATP + dephospho-[[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase] Rattus norvegicus Sprague-Dawley phosphorylation activates EC 2.7.1.109 ADP + [[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase]
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.3 Rattus norvegicus
-
Sprague-Dawley
-
2.7.11.3 Rattus norvegicus Sprague-Dawley
-
Sprague-Dawley
-
2.7.11.31 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.11.3 partial Rattus norvegicus
2.7.11.31 partial Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.3 liver
-
Rattus norvegicus
-
2.7.11.31 liver
-
Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.3 ATP + dephospho-[[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase]
-
Rattus norvegicus ADP + [[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase]
-
?
2.7.11.3 ATP + dephospho-[[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase] phosphorylation activates EC 2.7.1.109 Rattus norvegicus ADP + [[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase]
-
?
2.7.11.3 ATP + dephospho-[[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase]
-
Rattus norvegicus Sprague-Dawley ADP + [[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase]
-
?
2.7.11.3 ATP + dephospho-[[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase] phosphorylation activates EC 2.7.1.109 Rattus norvegicus Sprague-Dawley ADP + [[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase]
-
?
2.7.11.31 ATP + [hydroxymethylglutaryl-CoA reductase (NADPH)]
-
Rattus norvegicus ADP + [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate
-
?
2.7.11.31 ATP + [hydroxymethylglutaryl-CoA reductase (NADPH)]
-
Rattus norvegicus Sprague-Dawley ADP + [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate
-
?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.11.3 37
-
-
Rattus norvegicus
2.7.11.31 37
-
assay at Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.11.3 7
-
assay at Rattus norvegicus