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Literature summary extracted from

  • Friedrich, B.; Friedrich, C.G.; Magasanik, B.
    Catabolic N2-acetylornithine 5-aminotransferase of Klebsiella aerogenes: control of synthesis by induction, catabolite repression, and activation by glutamine synthetase (1978), J. Bacteriol., 133, 686-691.
    View publication on PubMedView publication on EuropePMC

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.6.1.11 0.7
-
 2-oxoglutarate cosubstrate acetylornithine Klebsiella aerogenes
2.6.1.11 1.1
-
 N2-Acetyl-L-ornithine
-
 Klebsiella aerogenes

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.6.1.11 27000
-
 2 * 27000, SDS-PAGE Klebsiella aerogenes
2.6.1.11 59000
-
 arginine-inducible catabolic enzyme, gel filtration Klebsiella aerogenes

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.6.1.11 N2-acetyl-L-ornithine + 2-oxoglutarate Klebsiella aerogenes arginine degradation, arginine-inducible catabolic enzyme N-acetyl-L-glutamate-gamma-semialdehyde + L-glutamate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.6.1.11 Klebsiella aerogenes
-
 one arginine-inducible form and one arginine-repressible form
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.6.1.11 arginine-inducible form, partial purification of arginine-repressible form Klebsiella aerogenes

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.6.1.11 34.6
-
-
 Klebsiella aerogenes

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.6.1.11 additional information not: putrescine Klebsiella aerogenes ?
-
 ?
2.6.1.11 additional information purified enzyme also has activity of EC 2.6.1.13 Klebsiella aerogenes ?
-
 ?
2.6.1.11 additional information 4-aminobutyrate Klebsiella aerogenes ?
-
 ?
2.6.1.11 N2-acetyl-L-ornithine + 2-oxoglutarate arginine degradation, arginine-inducible catabolic enzyme Klebsiella aerogenes N-acetyl-L-glutamate-gamma-semialdehyde + L-glutamate
-
 ?
2.6.1.11 N2-acetyl-L-ornithine + 2-oxohexanedioic acid i.e. 2-ketoadipate Klebsiella aerogenes N-acetyl-L-glutamate 5-semialdehyde + 2-aminohexanedioic acid
-
 ?
2.6.1.11 Nalpha-acetyl-L-ornithine + 2-oxoglutarate
-
 Klebsiella aerogenes N-acetyl-L-glutamate 5-semialdehyde + L-glutamate
-
 ?

Subunits

EC Number Subunits Comment Organism
2.6.1.11 dimer 2 * 27000, SDS-PAGE Klebsiella aerogenes

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.6.1.11 8.1
-
 biosynthetic enzyme Klebsiella aerogenes
2.6.1.11 8.7
-
 catabolic enzyme Klebsiella aerogenes

pH Range

EC Number pH Minimum pH Maximum Comment Organism
2.6.1.11 6.5 10 active over the range, catabolic enzyme Klebsiella aerogenes

Cofactor

EC Number Cofactor Comment Organism Structure
2.6.1.11 pyridoxal 5'-phosphate a pyridoxal phosphate protein Klebsiella aerogenes