EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.3.1.168 | arsenite | strong inhibition | Bos taurus | |
2.3.1.168 | CoA | product inhibition, competitive to acyl-CoA, noncompetitive to dihydrolipoamide | Bos taurus | |
2.3.1.168 | Mg2+ | - |
Bos taurus | |
2.3.1.168 | additional information | limited proteolysis by trypsin results in the complete loss of the overall activity of the enzyme complex, but does not affect dihydrolipoyllysine-residue (2-methylpropanoyl)transferase activity; NEM and thiamine diphosphate have no effect | Bos taurus |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.3.1.168 | additional information | - |
additional information | kinetics | Bos taurus | |
2.3.1.168 | 0.05 | - |
isovaleryl-CoA | pH 7.4, 37°C | Bos taurus | |
2.3.1.168 | 0.1 | - |
isobutyryl-CoA | pH 7.4, 37°C | Bos taurus | |
2.3.1.168 | 0.11 | - |
acetyl-CoA | pH 7.4, 37°C | Bos taurus | |
2.3.1.168 | 2 | - |
6,8-bis(sulfanyl)octanamide | pH 7.4, 37°C | Bos taurus |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
2.3.1.168 | 52600 | - |
x * 52600, SDS-PAGE | Bos taurus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.3.1.168 | 2-methylpropanoyl-CoA + enzyme N6-(dihydrolipoyl)lysine | Bos taurus | - |
CoA + enzyme N6-(S-[2-methylpropanoyl]dihydrolipoyl)lysine | - |
r |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.3.1.168 | Bos taurus | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
2.3.1.168 | - |
Bos taurus |
EC Number | Reaction | Comment | Organism | Reaction ID |
---|---|---|---|---|
2.3.1.168 | 2-methylpropanoyl-CoA + enzyme N6-(dihydrolipoyl)lysine = CoA + enzyme N6-(S-[2-methylpropanoyl]dihydrolipoyl)lysine | random bi bi mechanism | Bos taurus |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.3.1.168 | kidney | - |
Bos taurus | - |
2.3.1.168 | liver | - |
Bos taurus | - |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
2.3.1.168 | 2.38 | - |
partially purified E2 enzyme | Bos taurus |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.3.1.168 | 2-methylpropanoyl-CoA + dihydrolipoamide | - |
Bos taurus | CoA + S-2-methylpropanoyldihydrolipoamide | identification by mass spectrometry | r | |
2.3.1.168 | 2-methylpropanoyl-CoA + enzyme N6-(dihydrolipoyl)lysine | - |
Bos taurus | CoA + enzyme N6-(S-[2-methylpropanoyl]dihydrolipoyl)lysine | - |
r | |
2.3.1.168 | acetyl-CoA + dihydrolipoamide | low activity | Bos taurus | CoA + S-acetyldihydrolipoamide | - |
r | |
2.3.1.168 | isobutyryl-CoA + dihydrolipoamide | - |
Bos taurus | CoA + S-isobutyryldihydrolipoamide | - |
r | |
2.3.1.168 | isovaleryl-CoA + dihydrolipoamide | - |
Bos taurus | CoA + S-isovaleryldihydrolipoamide | - |
r |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
2.3.1.168 | ? | x * 52600, SDS-PAGE | Bos taurus |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.3.1.168 | More | enzyme is the E2 component of the multienzyme complex branched-chain alpha-keto acid dehydrogenase, i.e. branched-chain 2-oxo acid dehydrogenase | Bos taurus |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
2.3.1.168 | 37 | - |
assay at | Bos taurus |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
2.3.1.168 | 7.4 | - |
assay at | Bos taurus |