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Literature summary extracted from
- Iodothyronine deiodinases (2002), Methods Enzymol., 347, 125-167.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.21.99.3 | 3,3',5-triiodo-L-thyronine | induces enzyme | vertebrata |  |
| 1.21.99.3 | Epidermal growth factor | - |
Rattus norvegicus | |
| 1.21.99.3 | Epidermal growth factor | induces enzyme | vertebrata | |
| 1.21.99.3 | fibroblast growth factor | induces enzyme | vertebrata | |
| 1.21.99.3 | additional information | expression and function of 5-deiodinase are sensitive to thyroid hormone status, various cytokines and growth factors, severe illness, reactive oxygen species, a variety of hormones and signaling compounds, circadian rythm, and pharmacological agents | Homo sapiens | |
| 1.21.99.4 | 3,3',5-triiodo-L-thyronine | induces isozyme type I | vertebrata | |
| 1.21.99.4 | atrial natriuretic protein | induces isozyme type II via cGMP | vertebrata | |
| 1.21.99.4 | beta-adrenergic agonists | stimulates isozyme type II | vertebrata | |
| 1.21.99.4 | C-type natriuretic protein | induces isozyme type II via cGMP | vertebrata | |
| 1.21.99.4 | cAMP | - |
Rattus norvegicus | |
| 1.21.99.4 | cAMP | induces isozyme type I in thyroid gland only, induces isozyme type II | vertebrata | |
| 1.21.99.4 | Epidermal growth factor | - |
Rattus norvegicus | |
| 1.21.99.4 | fibroblast growth factor | induces isozymes type II, and I | vertebrata | |
| 1.21.99.4 | additional information | expression and function of the deiodinase isozymes are sensitive to thyroid hormone status, various cytokines and growth factors, severe illness, reactive oxygen species, a variety of hormones and signaling compounds, circadian rythm, and pharmacological agents | Homo sapiens | |
| 1.21.99.4 | Nicotine | stimulates isozyme type II | vertebrata | |
| 1.21.99.4 | Phorbol esters | induce isozyme type II via protein kinase C | vertebrata | |
| 1.21.99.4 | retinoic acid | - |
Rattus norvegicus | |
| 1.21.99.4 | retinoic acid | stimulates isozyme type I | vertebrata | |
| 1.21.99.4 | Se2+ | - |
Rattus norvegicus | |
| 1.21.99.4 | Se2+ | severe selenium deficiency leads to a decrease in activity of isozyme type I in liver, kidney, and several other organs, but not in the thyroid gland, the central nervous system, and several other endrocrine organs | Homo sapiens | |
| 1.21.99.4 | Se2+ | stimulates isozyme type I, absolutely required, isozymes of the deiodinase enzyme family are selenoproteins | vertebrata | |
| 1.21.99.4 | testosterone | stimulates isozyme type I in liver | vertebrata | |
| 1.21.99.4 | thyroid stimulating hormone | induces isozyme type I | vertebrata |
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 1.21.99.3 | medicine | expression and function of the 5-deiodinase and 5-deiodinase isozymes are sensitive to thyroid hormone status, various cytokines and growth factors, severe illness, reactive oxygen species, a variety of hormones and signaling compounds, circadian rythm, and pharmacological agents, and therefore might be useful in sensor function of physiology and pathophysiology | Homo sapiens |
| 1.21.99.4 | medicine | expression and function of the 5-deiodinase and 5-deiodinase isozymes are sensitive to thyroid hormone status, various cytokines and growth factors, severe illness, reactive oxygen species, a variety of hormones and signaling compounds, circadian rythm, and pharmacological agents, and therefore might be useful in sensor function of physiology and pathophysiology | Homo sapiens |
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 1.21.99.4 | isozyme type I, mapping on chromosome 1p32-p33, DNA sequence analysis | Homo sapiens |
| 1.21.99.4 | isozyme type I, mapping on chromosome 4 | Mus musculus |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.21.99.3 | iopanoic acid | - |
Homo sapiens | |
| 1.21.99.3 | iopanoic acid | - |
vertebrata | |
| 1.21.99.3 | additional information | expression and function of the 5-deiodinase and 5-deiodinase isozymes are sensitive to thyroid hormone status, various cytokines and growth factors, severe illness, reactive oxygen species, a variety of hormones and signaling compounds, circadian rythm, and pharmacological agents, and therefore might be useful in sensor function of physiology and pathophysiology | Homo sapiens | |
| 1.21.99.4 | 3,3',5'-triiodo-L-thyronine | - |
Homo sapiens | |
| 1.21.99.4 | 3,3',5'-triiodo-L-thyronine | isozyme type II, rapid inactivation in brain | Rattus norvegicus | |
| 1.21.99.4 | 3,3',5'-triiodo-L-thyronine | inhibits expression of isozyme type II | vertebrata | |
| 1.21.99.4 | aurothioglucose | - |
Homo sapiens | |
| 1.21.99.4 | aurothioglucose | isoyzme type I | vertebrata | |
| 1.21.99.4 | Ca2+ | inhibits expression of isozyme type I in thyroid gland | vertebrata | |
| 1.21.99.4 | dexamethasone | inhibits expression of isozyme type I | vertebrata | |
| 1.21.99.4 | iodoacetate | isozyme type I | vertebrata | |
| 1.21.99.4 | iopanoic acid | both isozyme type I and type II | Homo sapiens | |
| 1.21.99.4 | iopanoic acid | both isozyme type I and type II | vertebrata | |
| 1.21.99.4 | L-thyroxine | isozyme type II | vertebrata | |
| 1.21.99.4 | additional information | expression and function of the 5-deiodinase and 5-deiodinase isozymes are sensitive to thyroid hormone status, various cytokines and growth factors, severe illness, reactive oxygen species, a variety of hormones and signaling compounds, circadian rythm, and pharmacological agents, and therefore might be useful in sensor function of physiology and pathophysiology | Homo sapiens | |
| 1.21.99.4 | propylthiouracil | isozyme type I | vertebrata | |
| 1.21.99.4 | thyroxine | isozyme type II, rapid inactivation in brain | Rattus norvegicus | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.21.99.3 | additional information | - |
additional information | review on enzyme and 5-deiodinase isoforms type I and II | Homo sapiens | |
| 1.21.99.3 | additional information | - |
additional information | review on enzyme and 5-deiodinase isoforms type I and II | Rattus norvegicus | |
| 1.21.99.3 | additional information | - |
additional information | review on enzyme and 5-deiodinase isoforms type I and II | vertebrata | |
| 1.21.99.4 | additional information | - |
additional information | review on enzyme isoforms type I and II and 5-deiodinase, type III | Homo sapiens | |
| 1.21.99.4 | additional information | - |
additional information | review on enzyme isoforms type I and II and 5-deiodinase, type III | Rattus norvegicus | |
| 1.21.99.4 | additional information | - |
additional information | review on enzyme isoforms type I and II and 5-deiodinase, type III | Bos taurus | |
| 1.21.99.4 | additional information | - |
additional information | review on enzyme isoforms type I and II and 5-deiodinase, type III | vertebrata |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 1.21.99.3 | microsome | - |
Homo sapiens | - |
- |
| 1.21.99.3 | additional information | membrane association is not essential for maintenance of functional activity | Rattus norvegicus | - |
- |
| 1.21.99.3 | additional information | subcellular localization of the different isozyme types in different tissues, overview | vertebrata | - |
- |
| 1.21.99.4 | endoplasmic reticulum | liver, smooth and rough, isozyme type I, at the cytosolic surface | vertebrata | 5783 | - |
| 1.21.99.4 | endoplasmic reticulum | anterior pituitary gland, isozyme type I | Bos taurus | 5783 | - |
| 1.21.99.4 | microsome | - |
Mus musculus | - |
- |
| 1.21.99.4 | microsome | - |
Homo sapiens | - |
- |
| 1.21.99.4 | microsome | - |
vertebrata | - |
- |
| 1.21.99.4 | microsome | isozyme type I, liver | Rattus norvegicus | - |
- |
| 1.21.99.4 | mitochondrion | - |
Rattus norvegicus | 5739 | - |
| 1.21.99.4 | mitochondrion | - |
vertebrata | 5739 | - |
| 1.21.99.4 | additional information | membrane association is not essential for maintenance of functional activity | Rattus norvegicus | - |
- |
| 1.21.99.4 | additional information | subcellular localization of the different isozyme types in different tissues, overview | vertebrata | - |
- |
| 1.21.99.4 | plasma membrane | at the inner leaflet of the basolateral plasma membrane, isozyme type I, kidney | vertebrata | 5886 | - |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 1.21.99.4 | 27000 | - |
2 * 27000, isozyme type I | Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.21.99.3 | 3,3',5-triiodo-L-thyronine + AH2 | Mus musculus | - |
3,3'-diiodo-L-thyronine + iodide + A + H+ | hormonally inactive | ? | |
| 1.21.99.3 | 3,3',5-triiodo-L-thyronine + AH2 | Homo sapiens | - |
3,3'-diiodo-L-thyronine + iodide + A + H+ | hormonally inactive | ? | |
| 1.21.99.3 | 3,3',5-triiodo-L-thyronine + AH2 | Rattus norvegicus | - |
3,3'-diiodo-L-thyronine + iodide + A + H+ | hormonally inactive | ? | |
| 1.21.99.3 | 3,3',5-triiodo-L-thyronine + AH2 | vertebrata | - |
3,3'-diiodo-L-thyronine + iodide + A + H+ | hormonally inactive | ? | |
| 1.21.99.3 | L-thyroxine + AH2 | Mus musculus | enzyme III performs the inactivation of 3,3',5,5'-tetraiodo-L-thyronine | 3,3',5'-triiodo-L-thyronine + iodide + A + H+ | hormonally inactive | ? | |
| 1.21.99.3 | L-thyroxine + AH2 | Homo sapiens | enzyme III performs the inactivation of 3,3',5,5'-tetraiodo-L-thyronine | 3,3',5'-triiodo-L-thyronine + iodide + A + H+ | hormonally inactive | ? | |
| 1.21.99.3 | L-thyroxine + AH2 | vertebrata | enzyme III performs the inactivation of 3,3',5,5'-tetraiodo-L-thyronine | 3,3',5'-triiodo-L-thyronine + iodide + A + H+ | hormonally inactive | ? | |
| 1.21.99.3 | L-thyroxine + AH2 | Rattus norvegicus | enzyme performs the inactivation of 3,3',5,5'-tetraiodo-L-thyronine | 3,3',5'-triiodo-L-thyronine + iodide + A + H+ | hormonally inactive | ? | |
| 1.21.99.3 | additional information | Rattus norvegicus | enzyme plays a critical role in regulating and maintaining the local 3,3',5-triiodo-L-thyronine content | ? | - |
? | |
| 1.21.99.3 | additional information | Mus musculus | isozyme type III performs the inactivation of 3,3',5,5'-tetraiodo-L-thyronine and enzyme plays a critical role in regulating and maintaining the local 3,3',5-triiodo-L-thyronine content | ? | - |
? | |
| 1.21.99.3 | additional information | Homo sapiens | isozyme type III performs the inactivation of 3,3',5,5'-tetraiodo-L-thyronine and enzyme plays a critical role in regulating and maintaining the local 3,3',5-triiodo-L-thyronine content | ? | - |
? | |
| 1.21.99.3 | additional information | vertebrata | isozyme type III performs the inactivation of 3,3',5,5'-tetraiodo-L-thyronine and enzyme plays a critical role in regulating and maintaining the local 3,3',5-triiodo-L-thyronine content | ? | - |
? | |
| 1.21.99.4 | 3,3',5'-triiodo-L-thyronine + AH2 | Mus musculus | isozyme type I | 3,3'-diiodo-L-thyronine + iodide + A + H+ | - |
? | |
| 1.21.99.4 | 3,3',5'-triiodo-L-thyronine + AH2 | Homo sapiens | isozyme type I | 3,3'-diiodo-L-thyronine + iodide + A + H+ | - |
? | |
| 1.21.99.4 | 3,3',5'-triiodo-L-thyronine + AH2 | Rattus norvegicus | isozyme type I | 3,3'-diiodo-L-thyronine + iodide + A + H+ | - |
? | |
| 1.21.99.4 | 3,3',5'-triiodo-L-thyronine + AH2 | vertebrata | isozyme type I | 3,3'-diiodo-L-thyronine + iodide + A + H+ | - |
? | |
| 1.21.99.4 | L-thyroxine + AH2 | Rattus norvegicus | isozymes type II and I, production of 3,3',5-triiodo-L-thyronine | 3,3',5'-triiodo-L-thyronine + iodide + A + H+ | hormonally inactive | ? | |
| 1.21.99.4 | L-thyroxine + AH2 | vertebrata | isozymes type II and I, production of 3,3',5-triiodo-L-thyronine | 3,3',5'-triiodo-L-thyronine + iodide + A + H+ | hormonally inactive | ? | |
| 1.21.99.4 | L-thyroxine + AH2 | Mus musculus | - |
3,3',5-triiodo-L-thyronine + iodide + A + H+ | from microsomal enzyme complex, 3,3',5-triiodo-L-thyronine is thyromimetically active | ? | |
| 1.21.99.4 | L-thyroxine + AH2 | Homo sapiens | - |
3,3',5-triiodo-L-thyronine + iodide + A + H+ | from microsomal enzyme complex, 3,3',5-triiodo-L-thyronine is thyromimetically active | ? | |
| 1.21.99.4 | L-thyroxine + AH2 | Rattus norvegicus | - |
3,3',5-triiodo-L-thyronine + iodide + A + H+ | from microsomal enzyme complex, 3,3',5-triiodo-L-thyronine is thyromimetically active | ? | |
| 1.21.99.4 | L-thyroxine + AH2 | vertebrata | - |
3,3',5-triiodo-L-thyronine + iodide + A + H+ | from microsomal enzyme complex, 3,3',5-triiodo-L-thyronine is thyromimetically active | ? | |
| 1.21.99.4 | L-thyroxine + AH2 | Mus musculus | isozymes type II and I, production of 3,3',5-triiodo-L-thyronine | 3,5,3'-triiodo-L-thyronine + iodide + A + H+ | hormonally inactive | ? | |
| 1.21.99.4 | L-thyroxine + AH2 | Homo sapiens | isozymes type II and I, production of 3,3',5-triiodo-L-thyronine | 3,5,3'-triiodo-L-thyronine + iodide + A + H+ | hormonally inactive | ? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.21.99.3 | Bos taurus | - |
- |
- |
| 1.21.99.3 | Homo sapiens | - |
- |
- |
| 1.21.99.3 | Mus musculus | - |
- |
- |
| 1.21.99.3 | Rattus norvegicus | - |
- |
- |
| 1.21.99.3 | vertebrata | - |
- |
- |
| 1.21.99.4 | Bos taurus | - |
type I and type II enzyme isoforms | - |
| 1.21.99.4 | Homo sapiens | - |
type I and type II enzyme isoforms | - |
| 1.21.99.4 | Mus musculus | - |
type I and type II enzyme isoforms | - |
| 1.21.99.4 | Rattus norvegicus | - |
type I and type II enzyme isoforms | - |
| 1.21.99.4 | vertebrata | - |
type I and type II enzyme isoforms | - |
Reaction
| EC Number | Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|---|
| 1.21.99.3 | 3,3',5'-triiodo-L-thyronine + iodide + acceptor + H+ = L-thyroxine + reduced acceptor | both 5'-deiodinase isoforms and 5-deiodinase contain a selenocysteine residue at the active site | vertebrata | |
| 1.21.99.4 | 3,3',5-triiodo-L-thyronine + iodide + acceptor + H+ = L-thyroxine + reduced acceptor | isozyme type I, reaction mechanism, both 5-deiodinase isoforms and 5-deiodinase contain a selenocysteine residue at the active site | Mus musculus | |
| 1.21.99.4 | 3,3',5-triiodo-L-thyronine + iodide + acceptor + H+ = L-thyroxine + reduced acceptor | isozyme type I, reaction mechanism, both 5-deiodinase isoforms and 5-deiodinase contain a selenocysteine residue at the active site | Rattus norvegicus | |
| 1.21.99.4 | 3,3',5-triiodo-L-thyronine + iodide + acceptor + H+ = L-thyroxine + reduced acceptor | isozyme type I, reaction mechanism, both 5-deiodinase isoforms and 5-deiodinase contain a selenocysteine residue at the active site | Bos taurus | |
| 1.21.99.4 | 3,3',5-triiodo-L-thyronine + iodide + acceptor + H+ = L-thyroxine + reduced acceptor | isozyme type I, reaction mechanism, both 5-deiodinase isoforms and 5-deiodinase contain a selenocysteine residue at the active site | vertebrata |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.21.99.3 | brain | - |
Mus musculus | - |
| 1.21.99.3 | brain | - |
Homo sapiens | - |
| 1.21.99.3 | brain | - |
Rattus norvegicus | - |
| 1.21.99.3 | brain | - |
vertebrata | - |
| 1.21.99.3 | additional information | not: kidney, healthy adult liver, pituitary gland, thyroid gland | Mus musculus | - |
| 1.21.99.3 | additional information | not: kidney, healthy adult liver, pituitary gland, thyroid gland | Homo sapiens | - |
| 1.21.99.3 | additional information | not: kidney, healthy adult liver, pituitary gland, thyroid gland | vertebrata | - |
| 1.21.99.3 | placenta | - |
Mus musculus | - |
| 1.21.99.3 | placenta | - |
Homo sapiens | - |
| 1.21.99.3 | placenta | - |
Rattus norvegicus | - |
| 1.21.99.3 | placenta | - |
vertebrata | - |
| 1.21.99.4 | adipocyte | - |
Rattus norvegicus | - |
| 1.21.99.4 | adipocyte | isozyme type II | Mus musculus | - |
| 1.21.99.4 | adipocyte | isozyme type II | vertebrata | - |
| 1.21.99.4 | brain | isozyme type II | Mus musculus | - |
| 1.21.99.4 | brain | isozyme type II | vertebrata | - |
| 1.21.99.4 | brown adipose tissue | isozyme type II | Mus musculus | - |
| 1.21.99.4 | brown adipose tissue | isozyme type II | Rattus norvegicus | - |
| 1.21.99.4 | brown adipose tissue | isozyme type II | vertebrata | - |
| 1.21.99.4 | central nervous system | isozyme type I | Homo sapiens | - |
| 1.21.99.4 | epithelium | of kidney, isozyme type I | Mus musculus | - |
| 1.21.99.4 | epithelium | of kidney, isozyme type I | vertebrata | - |
| 1.21.99.4 | glial cell | isozyme type II | Mus musculus | - |
| 1.21.99.4 | glial cell | isozyme type II | vertebrata | - |
| 1.21.99.4 | harderian gland | isozyme type II vertebrata | Mus musculus | - |
| 1.21.99.4 | harderian gland | isozyme type II vertebrata | vertebrata | - |
| 1.21.99.4 | heart | isozyme type I | Mus musculus | - |
| 1.21.99.4 | heart | isozyme type I | vertebrata | - |
| 1.21.99.4 | hepatocyte | - |
Homo sapiens | - |
| 1.21.99.4 | kidney | isozyme type I | Mus musculus | - |
| 1.21.99.4 | kidney | isozyme type I | Homo sapiens | - |
| 1.21.99.4 | kidney | isozyme type I | vertebrata | - |
| 1.21.99.4 | liver | isozyme type I | Mus musculus | - |
| 1.21.99.4 | liver | isozyme type I | Homo sapiens | - |
| 1.21.99.4 | liver | isozyme type I | Rattus norvegicus | - |
| 1.21.99.4 | liver | isozyme type I | vertebrata | - |
| 1.21.99.4 | additional information | severe selenium deficiency leads to a decrease in activity of isozyme type I in liver, kidney, and several other organs, but not in the thyroid gland, the central nervous system, and several other endrocrine organs | Homo sapiens | - |
| 1.21.99.4 | pineal gland | isozyme type II | Mus musculus | - |
| 1.21.99.4 | pineal gland | isozyme type II | vertebrata | - |
| 1.21.99.4 | pituitary gland | isozyme type I | Rattus norvegicus | - |
| 1.21.99.4 | pituitary gland | anterior, isozyme type I | Bos taurus | - |
| 1.21.99.4 | pituitary gland | anterior, isozyme type II, isozyme type I | Mus musculus | - |
| 1.21.99.4 | pituitary gland | anterior, isozyme type II, isozyme type I | vertebrata | - |
| 1.21.99.4 | placenta | isozyme type II | Mus musculus | - |
| 1.21.99.4 | placenta | isozyme type II | Rattus norvegicus | - |
| 1.21.99.4 | skin | - |
Rattus norvegicus | - |
| 1.21.99.4 | skin | isozyme type II | Mus musculus | - |
| 1.21.99.4 | skin | isozyme type II | vertebrata | - |
| 1.21.99.4 | tanycyte | isozyme type II | Mus musculus | - |
| 1.21.99.4 | tanycyte | isozyme type II | vertebrata | - |
| 1.21.99.4 | thymus | isozyme type II | Mus musculus | - |
| 1.21.99.4 | thymus | isozyme type II | vertebrata | - |
| 1.21.99.4 | thyroid gland | - |
Homo sapiens | - |
| 1.21.99.4 | thyroid gland | isozyme type I | Rattus norvegicus | - |
| 1.21.99.4 | thyroid gland | isozyme types I and II | Mus musculus | - |
| 1.21.99.4 | thyroid gland | isozyme types I and II | vertebrata | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 1.21.99.3 | additional information | - |
overview on assay methods | Mus musculus |
| 1.21.99.3 | additional information | - |
overview on assay methods | Rattus norvegicus |
| 1.21.99.3 | additional information | - |
overview on assay methods | vertebrata |
| 1.21.99.4 | additional information | - |
overview on assay methods | Mus musculus |
| 1.21.99.4 | additional information | - |
overview on assay methods | Rattus norvegicus |
| 1.21.99.4 | additional information | - |
overview on assay methods | Bos taurus |
| 1.21.99.4 | additional information | - |
overview on assay methods | vertebrata |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.21.99.3 | 3,3',5-triiodo-L-thyronine + AH2 | - |
Mus musculus | 3,3'-diiodo-L-thyronine + iodide + A + H+ | hormonally inactive | ? | |
| 1.21.99.3 | 3,3',5-triiodo-L-thyronine + AH2 | - |
Homo sapiens | 3,3'-diiodo-L-thyronine + iodide + A + H+ | hormonally inactive | ? | |
| 1.21.99.3 | 3,3',5-triiodo-L-thyronine + AH2 | - |
Rattus norvegicus | 3,3'-diiodo-L-thyronine + iodide + A + H+ | hormonally inactive | ? | |
| 1.21.99.3 | 3,3',5-triiodo-L-thyronine + AH2 | - |
Bos taurus | 3,3'-diiodo-L-thyronine + iodide + A + H+ | hormonally inactive | ? | |
| 1.21.99.3 | 3,3',5-triiodo-L-thyronine + AH2 | - |
vertebrata | 3,3'-diiodo-L-thyronine + iodide + A + H+ | hormonally inactive | ? | |
| 1.21.99.3 | L-thyroxine + AH2 | enzyme III performs the inactivation of 3,3',5,5'-tetraiodo-L-thyronine | Mus musculus | 3,3',5'-triiodo-L-thyronine + iodide + A + H+ | hormonally inactive | ? | |
| 1.21.99.3 | L-thyroxine + AH2 | enzyme III performs the inactivation of 3,3',5,5'-tetraiodo-L-thyronine | Homo sapiens | 3,3',5'-triiodo-L-thyronine + iodide + A + H+ | hormonally inactive | ? | |
| 1.21.99.3 | L-thyroxine + AH2 | enzyme III performs the inactivation of 3,3',5,5'-tetraiodo-L-thyronine | vertebrata | 3,3',5'-triiodo-L-thyronine + iodide + A + H+ | hormonally inactive | ? | |
| 1.21.99.3 | L-thyroxine + AH2 | enzyme performs the inactivation of 3,3',5,5'-tetraiodo-L-thyronine | Rattus norvegicus | 3,3',5'-triiodo-L-thyronine + iodide + A + H+ | hormonally inactive | ? | |
| 1.21.99.3 | L-thyroxine + AH2 | enzyme performs the inactivation of 3,3',5,5'-tetraiodo-L-thyronine and plays a critical role in regulating and maintaining the local 3,3',5-triiodo-L-thyronine content | Mus musculus | 3,3',5'-triiodo-L-thyronine + iodide + A + H+ | - |
? | |
| 1.21.99.3 | L-thyroxine + AH2 | enzyme performs the inactivation of 3,3',5,5'-tetraiodo-L-thyronine and plays a critical role in regulating and maintaining the local 3,3',5-triiodo-L-thyronine content | Homo sapiens | 3,3',5'-triiodo-L-thyronine + iodide + A + H+ | - |
? | |
| 1.21.99.3 | L-thyroxine + AH2 | enzyme performs the inactivation of 3,3',5,5'-tetraiodo-L-thyronine and plays a critical role in regulating and maintaining the local 3,3',5-triiodo-L-thyronine content | Rattus norvegicus | 3,3',5'-triiodo-L-thyronine + iodide + A + H+ | - |
? | |
| 1.21.99.3 | L-thyroxine + AH2 | enzyme performs the inactivation of 3,3',5,5'-tetraiodo-L-thyronine and plays a critical role in regulating and maintaining the local 3,3',5-triiodo-L-thyronine content | Bos taurus | 3,3',5'-triiodo-L-thyronine + iodide + A + H+ | - |
? | |
| 1.21.99.3 | L-thyroxine + AH2 | enzyme performs the inactivation of 3,3',5,5'-tetraiodo-L-thyronine and plays a critical role in regulating and maintaining the local 3,3',5-triiodo-L-thyronine content | vertebrata | 3,3',5'-triiodo-L-thyronine + iodide + A + H+ | - |
? | |
| 1.21.99.3 | additional information | enzyme plays a critical role in regulating and maintaining the local 3,3',5-triiodo-L-thyronine content | Rattus norvegicus | ? | - |
? | |
| 1.21.99.3 | additional information | isozyme type III performs the inactivation of 3,3',5,5'-tetraiodo-L-thyronine and enzyme plays a critical role in regulating and maintaining the local 3,3',5-triiodo-L-thyronine content | Mus musculus | ? | - |
? | |
| 1.21.99.3 | additional information | isozyme type III performs the inactivation of 3,3',5,5'-tetraiodo-L-thyronine and enzyme plays a critical role in regulating and maintaining the local 3,3',5-triiodo-L-thyronine content | Homo sapiens | ? | - |
? | |
| 1.21.99.3 | additional information | isozyme type III performs the inactivation of 3,3',5,5'-tetraiodo-L-thyronine and enzyme plays a critical role in regulating and maintaining the local 3,3',5-triiodo-L-thyronine content | vertebrata | ? | - |
? | |
| 1.21.99.3 | additional information | selenium-level of cells influences the enzyme activity | Homo sapiens | ? | - |
? | |
| 1.21.99.4 | 3,3',5'-triiodo-L-thyronine + AH2 | isozyme type I | Mus musculus | 3,3'-diiodo-L-thyronine + iodide + A + H+ | - |
? | |
| 1.21.99.4 | 3,3',5'-triiodo-L-thyronine + AH2 | isozyme type I | Homo sapiens | 3,3'-diiodo-L-thyronine + iodide + A + H+ | - |
? | |
| 1.21.99.4 | 3,3',5'-triiodo-L-thyronine + AH2 | isozyme type I | Rattus norvegicus | 3,3'-diiodo-L-thyronine + iodide + A + H+ | - |
? | |
| 1.21.99.4 | 3,3',5'-triiodo-L-thyronine + AH2 | isozyme type I | vertebrata | 3,3'-diiodo-L-thyronine + iodide + A + H+ | - |
? | |
| 1.21.99.4 | 3,3',5'-triiodo-L-thyronine + AH2 | isozyme type I: degradation of 3,3',5'-triiodo-L-thyronine | Mus musculus | 3,3'-diiodo-L-thyronine + iodide + A + H+ | hormonally inactive | ? | |
| 1.21.99.4 | 3,3',5'-triiodo-L-thyronine + AH2 | isozyme type I: degradation of 3,3',5'-triiodo-L-thyronine | Rattus norvegicus | 3,3'-diiodo-L-thyronine + iodide + A + H+ | hormonally inactive | ? | |
| 1.21.99.4 | 3,3',5'-triiodo-L-thyronine + AH2 | isozyme type I, degradation of 3,3',5'-triiodo-L-thyronine | Homo sapiens | 3,3'-diiodo-L-thyronine + iodide + A + H+ | hormonally inactive | ? | |
| 1.21.99.4 | 3,3',5'-triiodo-L-thyronine + AH2 | isozyme type I, degradation of 3,3',5'-triiodo-L-thyronine | Bos taurus | 3,3'-diiodo-L-thyronine + iodide + A + H+ | hormonally inactive | ? | |
| 1.21.99.4 | 3,3',5'-triiodo-L-thyronine + AH2 | isozyme type I, degradation of 3,3',5'-triiodo-L-thyronine | vertebrata | 3,3'-diiodo-L-thyronine + iodide + A + H+ | hormonally inactive | ? | |
| 1.21.99.4 | L-thyroxine + AH2 | isozymes type II and I, production of 3,3',5-triiodo-L-thyronine | Rattus norvegicus | 3,3',5'-triiodo-L-thyronine + iodide + A + H+ | hormonally inactive | ? | |
| 1.21.99.4 | L-thyroxine + AH2 | isozymes type II and I, production of 3,3',5-triiodo-L-thyronine | vertebrata | 3,3',5'-triiodo-L-thyronine + iodide + A + H+ | hormonally inactive | ? | |
| 1.21.99.4 | L-thyroxine + AH2 | - |
Mus musculus | 3,3',5-triiodo-L-thyronine + iodide + A + H+ | from microsomal enzyme complex, 3,3',5-triiodo-L-thyronine is thyromimetically active | ? | |
| 1.21.99.4 | L-thyroxine + AH2 | - |
Homo sapiens | 3,3',5-triiodo-L-thyronine + iodide + A + H+ | from microsomal enzyme complex, 3,3',5-triiodo-L-thyronine is thyromimetically active | ? | |
| 1.21.99.4 | L-thyroxine + AH2 | - |
Rattus norvegicus | 3,3',5-triiodo-L-thyronine + iodide + A + H+ | from microsomal enzyme complex, 3,3',5-triiodo-L-thyronine is thyromimetically active | ? | |
| 1.21.99.4 | L-thyroxine + AH2 | - |
Bos taurus | 3,3',5-triiodo-L-thyronine + iodide + A + H+ | from microsomal enzyme complex, 3,3',5-triiodo-L-thyronine is thyromimetically active | ? | |
| 1.21.99.4 | L-thyroxine + AH2 | - |
vertebrata | 3,3',5-triiodo-L-thyronine + iodide + A + H+ | from microsomal enzyme complex, 3,3',5-triiodo-L-thyronine is thyromimetically active | ? | |
| 1.21.99.4 | L-thyroxine + AH2 | isozyme type II | Mus musculus | 3,3',5-triiodo-L-thyronine + iodide + A + H+ | hormonally active | ? | |
| 1.21.99.4 | L-thyroxine + AH2 | isozyme type II | Homo sapiens | 3,3',5-triiodo-L-thyronine + iodide + A + H+ | hormonally active | ? | |
| 1.21.99.4 | L-thyroxine + AH2 | isozyme type II | Bos taurus | 3,3',5-triiodo-L-thyronine + iodide + A + H+ | hormonally active | ? | |
| 1.21.99.4 | L-thyroxine + AH2 | isozyme type II | vertebrata | 3,3',5-triiodo-L-thyronine + iodide + A + H+ | hormonally active | ? | |
| 1.21.99.4 | L-thyroxine + AH2 | isozyme type II | Rattus norvegicus | 3,5,3'-triiodo-L-thyronine + iodide + A + H+ | hormonally active | ? | |
| 1.21.99.4 | L-thyroxine + AH2 | isozymes type II and I, production of 3,3',5-triiodo-L-thyronine | Mus musculus | 3,5,3'-triiodo-L-thyronine + iodide + A + H+ | hormonally inactive | ? | |
| 1.21.99.4 | L-thyroxine + AH2 | isozymes type II and I, production of 3,3',5-triiodo-L-thyronine | Homo sapiens | 3,5,3'-triiodo-L-thyronine + iodide + A + H+ | hormonally inactive | ? | |
| 1.21.99.4 | additional information | selenium-level of cells influences the enzyme activity | Homo sapiens | ? | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 1.21.99.4 | dimer | 2 * 27000, isozyme type I | Rattus norvegicus |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 1.21.99.3 | 37 | - |
assay at | Homo sapiens |
| 1.21.99.3 | 37 | - |
assay at | Rattus norvegicus |
| 1.21.99.3 | 37 | - |
assay at | Bos taurus |
| 1.21.99.3 | 37 | - |
assay at | vertebrata |
| 1.21.99.4 | 37 | - |
assay at | Homo sapiens |
| 1.21.99.4 | 37 | - |
assay at | Rattus norvegicus |
| 1.21.99.4 | 37 | - |
assay at | Bos taurus |
| 1.21.99.4 | 37 | - |
assay at | vertebrata |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.21.99.3 | 8 | - |
assay at | Homo sapiens |
| 1.21.99.3 | 8 | - |
assay at | Bos taurus |
| 1.21.99.3 | 8 | - |
assay at | vertebrata |
| 1.21.99.4 | 8 | - |
assay at | Homo sapiens |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.21.99.3 | dithioerythritol | 5-20 mM, can be substituted by dithiothreititol | vertebrata | |
| 1.21.99.3 | dithioerythritol | 5-20 mM, can be substituted by dithiothreitol | Rattus norvegicus | |
| 1.21.99.3 | dithiothreitol | - |
Homo sapiens | |
| 1.21.99.3 | dithiothreitol | 5-20 mM, can be substituted by dithioerythritol | Rattus norvegicus | |
| 1.21.99.3 | dithiothreitol | 5-20 mM, can be substituted by dithioerythritol | vertebrata | |
| 1.21.99.4 | dithioerythritol | - |
Homo sapiens | |
| 1.21.99.4 | dithioerythritol | can be substituted by dithiothreitol, isozyme type II, 5-20 mM, isozyme type I, 2-5 mM | Rattus norvegicus | |
| 1.21.99.4 | dithioerythritol | can be substituted by dithiothreitol, isozyme type II, 5-20 mM, isozyme type I, 2-5 mM | vertebrata | |
| 1.21.99.4 | dithiothreitol | can be substituted by dithioerythritol, isozyme type II, 5-20 mM, isozyme type I, 2-5 mM | Rattus norvegicus | |
| 1.21.99.4 | dithiothreitol | can be substituted by dithioerythritol, isozyme type II, 5-20 mM, isozyme type I, 2-5 mM | vertebrata | |
| 1.21.99.4 | additional information | no activity with glutathione or thioredoxin in vivo, isozyme type I | Rattus norvegicus | |
| 1.21.99.4 | additional information | no activity with glutathione or thioredoxin in vivo, isozyme type I | vertebrata |
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Release 2023.1 (January 2023)
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