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Literature summary extracted from

  • Visser, T.J.; Schoenmakers, C.H.
    Characteristics of type III iodothyronine deiodinase (1992), Acta Med. Austriaca, 19 Suppl 1, 18-21.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.21.99.3 additional information
-
 additional information
-
 Homo sapiens
1.21.99.3 additional information
-
 additional information
-
 Rattus norvegicus
1.21.99.3 additional information
-
 additional information
-
 Platyrrhini
1.21.99.3 0.0000055
-
 3,3',5-triiodo-L-thyronine
-
 Rattus norvegicus
1.21.99.3 0.000037
-
 L-thyroxine
-
 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.21.99.3 microsome
-
 Lithobates catesbeianus
-
-
1.21.99.3 microsome isozyme type III Gallus gallus
-
-
1.21.99.3 microsome isozyme type III Homo sapiens
-
-
1.21.99.3 microsome isozyme type III Rattus norvegicus
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.21.99.3 additional information Rattus norvegicus 5-deiodinase activity in brain is slightly decreased in hypo- and slightly increased in hyperthyroidism ?
-
 ?
1.21.99.3 additional information Gallus gallus isozyme type III is a oncofetal enzyme, regulation ?
-
 ?
1.21.99.3 additional information Homo sapiens isozyme type III is a oncofetal enzyme, regulation ?
-
 ?
1.21.99.3 additional information Rattus norvegicus isozyme type III is a oncofetal enzyme, regulation ?
-
 ?
1.21.99.3 additional information Lithobates catesbeianus isozyme type III is a oncofetal enzyme, regulation ?
-
 ?
1.21.99.3 additional information Platyrrhini isozyme type III is a oncofetal enzyme, regulation ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.21.99.3 Gallus gallus
-
 isozyme type III
-
1.21.99.3 Homo sapiens
-
 isozyme type III
-
1.21.99.3 Lithobates catesbeianus
-
 isozyme type III
-
1.21.99.3 Lithobates catesbeianus
-
 tadpole
-
1.21.99.3 Platyrrhini
-
 isozyme type III
-
1.21.99.3 Rattus norvegicus
-
 isozyme type III
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.21.99.3 brain isozyme type III Gallus gallus
-
1.21.99.3 brain isozyme type III Homo sapiens
-
1.21.99.3 brain isozyme type III Rattus norvegicus
-
1.21.99.3 cerebral cortex isozyme type III Rattus norvegicus
-
1.21.99.3 colon carcinoma cell isozyme type III Homo sapiens
-
1.21.99.3 hepatocarcinoma cell isozyme type III Platyrrhini
-
1.21.99.3 intestine fetal Rattus norvegicus
-
1.21.99.3 intestine isozyme type III Rattus norvegicus
-
1.21.99.3 liver
-
 Homo sapiens
-
1.21.99.3 liver
-
 Rattus norvegicus
-
1.21.99.3 liver embryonic Gallus gallus
-
1.21.99.3 liver isozyme type III Gallus gallus
-
1.21.99.3 liver tadpole Lithobates catesbeianus
-
1.21.99.3 placenta isozyme type III Homo sapiens
-
1.21.99.3 placenta isozyme type III Rattus norvegicus
-
1.21.99.3 skin isozyme type III Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.21.99.3 3,3',5-triiodo-L-thyronine + AH2
-
 Platyrrhini 3,3'-diiodo-L-thyronine + iodide + A + H+
-
 ?
1.21.99.3 3,3',5-triiodo-L-thyronine + AH2 best substrate Gallus gallus 3,3'-diiodo-L-thyronine + iodide + A + H+
-
 ?
1.21.99.3 3,3',5-triiodo-L-thyronine + AH2 best substrate Homo sapiens 3,3'-diiodo-L-thyronine + iodide + A + H+
-
 ?
1.21.99.3 3,3',5-triiodo-L-thyronine + AH2 best substrate Rattus norvegicus 3,3'-diiodo-L-thyronine + iodide + A + H+
-
 ?
1.21.99.3 3,3',5-triiodo-L-thyronine + AH2 best substrate Lithobates catesbeianus 3,3'-diiodo-L-thyronine + iodide + A + H+
-
 ?
1.21.99.3 3,3',5-triiodo-L-thyronine + AH2 isozyme type III Gallus gallus 3,3'-diiodo-L-thyronine + iodide + A + H+
-
 ?
1.21.99.3 3,3',5-triiodo-L-thyronine + AH2 isozyme type III Homo sapiens 3,3'-diiodo-L-thyronine + iodide + A + H+
-
 ?
1.21.99.3 3,3',5-triiodo-L-thyronine + AH2 isozyme type III Rattus norvegicus 3,3'-diiodo-L-thyronine + iodide + A + H+
-
 ?
1.21.99.3 3,3',5-triiodo-L-thyronine + AH2 isozyme type III Lithobates catesbeianus 3,3'-diiodo-L-thyronine + iodide + A + H+
-
 ?
1.21.99.3 L-thyroxine + AH2 preferred substrate Gallus gallus 3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
 ?
1.21.99.3 L-thyroxine + AH2 preferred substrate Homo sapiens 3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
 ?
1.21.99.3 L-thyroxine + AH2 preferred substrate Rattus norvegicus 3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
 ?
1.21.99.3 L-thyroxine + AH2 preferred substrate Lithobates catesbeianus 3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
 ?
1.21.99.3 L-thyroxine + AH2 preferred substrate Platyrrhini 3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
 ?
1.21.99.3 L-thyroxine + AH2 isozyme type III Gallus gallus 3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
 ?
1.21.99.3 L-thyroxine + AH2 isozyme type III Homo sapiens 3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
 ?
1.21.99.3 L-thyroxine + AH2 isozyme type III Rattus norvegicus 3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
 ?
1.21.99.3 L-thyroxine + AH2 isozyme type III Lithobates catesbeianus 3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
 ?
1.21.99.3 L-thyroxine + AH2 isozyme type III Platyrrhini 3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
 ?
1.21.99.3 L-thyroxine + AH2 5-deiodinase activity Gallus gallus 3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
 ?
1.21.99.3 L-thyroxine + AH2 5-deiodinase activity Homo sapiens 3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
 ?
1.21.99.3 L-thyroxine + AH2 5-deiodinase activity Rattus norvegicus 3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
 ?
1.21.99.3 L-thyroxine + AH2 5-deiodinase activity Lithobates catesbeianus 3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
 ?
1.21.99.3 L-thyroxine + AH2 5-deiodinase activity Platyrrhini 3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
 ?
1.21.99.3 additional information isozyme type III predominantly performs 5-deiodination reactions, while isozymes type I and type II perform 5'-deiodination reactions Gallus gallus ?
-
 ?
1.21.99.3 additional information isozyme type III predominantly performs 5-deiodination reactions, while isozymes type I and type II perform 5'-deiodination reactions Homo sapiens ?
-
 ?
1.21.99.3 additional information isozyme type III predominantly performs 5-deiodination reactions, while isozymes type I and type II perform 5'-deiodination reactions Rattus norvegicus ?
-
 ?
1.21.99.3 additional information isozyme type III predominantly performs 5-deiodination reactions, while isozymes type I and type II perform 5'-deiodination reactions Lithobates catesbeianus ?
-
 ?
1.21.99.3 additional information isozyme type III predominantly performs 5-deiodination reactions, while isozymes type I and type II perform 5'-deiodination reactions Platyrrhini ?
-
 ?
1.21.99.3 additional information 5-deiodinase activity in brain is slightly decreased in hypo- and slightly increased in hyperthyroidism Rattus norvegicus ?
-
 ?
1.21.99.3 additional information isozyme type III is a oncofetal enzyme, regulation Gallus gallus ?
-
 ?
1.21.99.3 additional information isozyme type III is a oncofetal enzyme, regulation Homo sapiens ?
-
 ?
1.21.99.3 additional information isozyme type III is a oncofetal enzyme, regulation Rattus norvegicus ?
-
 ?
1.21.99.3 additional information isozyme type III is a oncofetal enzyme, regulation Lithobates catesbeianus ?
-
 ?
1.21.99.3 additional information isozyme type III is a oncofetal enzyme, regulation Platyrrhini ?
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.21.99.3 dithiothreitol cofactor, influences the kinetic parameters Gallus gallus
1.21.99.3 dithiothreitol cofactor, influences the kinetic parameters Homo sapiens
1.21.99.3 dithiothreitol cofactor, influences the kinetic parameters Rattus norvegicus
1.21.99.3 dithiothreitol cofactor, influences the kinetic parameters Lithobates catesbeianus
1.21.99.3 dithiothreitol cofactor, influences the kinetic parameters Platyrrhini
1.21.99.3 dithiothreitol i.e. DTT Gallus gallus
1.21.99.3 dithiothreitol i.e. DTT Homo sapiens
1.21.99.3 dithiothreitol i.e. DTT Rattus norvegicus
1.21.99.3 dithiothreitol i.e. DTT Lithobates catesbeianus
1.21.99.3 dithiothreitol i.e. DTT Platyrrhini
1.21.99.3 dithiothreitol optimal at 50-100 mM Gallus gallus
1.21.99.3 dithiothreitol optimal at 50-100 mM Homo sapiens
1.21.99.3 dithiothreitol optimal at 50-100 mM Rattus norvegicus
1.21.99.3 dithiothreitol optimal at 50-100 mM Lithobates catesbeianus
1.21.99.3 dithiothreitol optimal at 50-100 mM Platyrrhini