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Literature summary extracted from

  • Tanaka, K.; Shimatsu, A.; Imura, H.
    Iodothyronine 5-deiodinase in rat posterior pituitary (1992), Biochem. Biophys. Res. Commun., 188, 272-277.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.21.99.3 L-thyroxine + AH2 Rattus norvegicus 5-deiodinase activity 3,3',5'-triiodo-L-thyronine + iodide + A + H+ hormonally inactive ?

Organism

EC Number Organism UniProt Comment Textmining
1.21.99.3 Rattus norvegicus
-
 Wistar rats
-
1.21.99.3 Rattus norvegicus
-
 isozyme type III
-
1.21.99.3 Rattus norvegicus
-
 isozyme type II
-
1.21.99.3 Rattus norvegicus
-
 isozyme type I
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.21.99.3 pituitary gland posterior Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.21.99.3 0.00000024
-
 3,3',5-triiodo-L-thyronine 5-deiodination activity, isozyme type III, posterior pituitary gland Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.21.99.3 3,3',5-triiodo-L-thyronine + AH2 best substrate Rattus norvegicus 3,3'-diiodo-L-thyronine + iodide + A + H+
-
 ?
1.21.99.3 3,3',5-triiodo-L-thyronine + AH2 isozyme type III Rattus norvegicus 3,3'-diiodo-L-thyronine + iodide + A + H+
-
 ?
1.21.99.3 L-thyroxine + AH2 preferred substrate Rattus norvegicus 3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
 ?
1.21.99.3 L-thyroxine + AH2 isozyme type III Rattus norvegicus 3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
 ?
1.21.99.3 L-thyroxine + AH2 5-deiodinase activity Rattus norvegicus 3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
 ?
1.21.99.3 L-thyroxine + AH2 5-deiodinase activity Rattus norvegicus 3,3',5'-triiodo-L-thyronine + iodide + A + H+ hormonally inactive ?
1.21.99.3 L-thyroxine + AH2 preferred substrate Rattus norvegicus 3,3',5-triiodo-L-thyronine + iodide + A + H+
-
 ?
1.21.99.3 L-thyroxine + AH2 5'-deiodinase activity Rattus norvegicus 3,3',5-triiodo-L-thyronine + iodide + A + H+
-
 ?
1.21.99.3 L-thyroxine + AH2 isozyme type II Rattus norvegicus 3,3',5-triiodo-L-thyronine + iodide + A + H+
-
 ?
1.21.99.3 L-thyroxine + AH2 isozyme type I Rattus norvegicus 3,3',5-triiodo-L-thyronine + iodide + A + H+
-
 ?
1.21.99.3 additional information isozyme type III predominantly performs 5-deiodination reactions, while isozymes type I and type II perform 5'-deiodination reactions Rattus norvegicus ?
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.21.99.3 7 7.5 isozyme type III, 3,3',5-triiodo-L-thyronine 5-deiodinase activity Rattus norvegicus