EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
1.21.99.3 | microsome | 3,3',5,5'-tetraiodo-L-thyronine-5'-deiodinase and 3,3',5,5'-tetraiodo-L-thyronine-5-deiodinase are solely localized in liver microsomes | Rattus norvegicus | - |
- |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.21.99.3 | L-thyroxine + AH2 | Rattus norvegicus | 5-deiodinase activity | 3,3',5'-triiodo-L-thyronine + iodide + A + H+ | from microsomal enzyme complex, 3,3',5'-triiodo-L-thyronine is regulatory active | ? | |
1.21.99.3 | L-thyroxine + AH2 | Rattus norvegicus | 5'-deiodinase activity | 3,3',5-triiodo-L-thyronine + iodide + A + H+ | from microsomal enzyme complex, 3,3',5-triiodo-L-thyronine is thyromimetically active | ? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.21.99.3 | Rattus norvegicus | - |
- |
- |
EC Number | Reaction | Comment | Organism | Reaction ID |
---|---|---|---|---|
1.21.99.3 | 3,3',5'-triiodo-L-thyronine + iodide + acceptor + H+ = L-thyroxine + reduced acceptor | enzyme has both thyroxine 5-deiodinase and thyroxine 5'-deiodinase activities | Rattus norvegicus |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.21.99.3 | liver | - |
Rattus norvegicus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.21.99.3 | L-thyroxine + AH2 | 5-deiodinase activity | Rattus norvegicus | 3,3',5'-triiodo-L-thyronine + iodide + A + H+ | - |
? | |
1.21.99.3 | L-thyroxine + AH2 | 5-deiodinase activity | Rattus norvegicus | 3,3',5'-triiodo-L-thyronine + iodide + A + H+ | from microsomal enzyme complex, 3,3',5'-triiodo-L-thyronine is regulatory active | ? | |
1.21.99.3 | L-thyroxine + AH2 | 5'-deiodinase activity | Rattus norvegicus | 3,3',5-triiodo-L-thyronine + iodide + A + H+ | - |
? | |
1.21.99.3 | L-thyroxine + AH2 | 5'-deiodinase activity | Rattus norvegicus | 3,3',5-triiodo-L-thyronine + iodide + A + H+ | from microsomal enzyme complex, 3,3',5-triiodo-L-thyronine is thyromimetically active | ? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.21.99.3 | T4-5'-deiodinase | - |
Rattus norvegicus |
1.21.99.3 | T4-5-deiodinase | - |
Rattus norvegicus |