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Literature summary extracted from

  • Moini, H.; Guo, Q.; Packer, L.
    Enzyme inhibiton and protein-binding action of the procyanidin-rich french maritime pine bark extract, pycnogenol: effect on xanthine oxidase (2000), J. Agric. Food Chem., 48, 5630-5639.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.17.3.2 pycnogenol extract from french maritime pine bark, contains 75% (w/w) procyanidins formed by catechin and epicatechin but also taxifolin and phenolcarbonic acids and their glycosides, uncompetitive inhibitor, 0.01 mg/ml, 35% inhibition, 0.1 mg/ml, 80% inhibition, enzyme recovers activity upon dissociation of pycnogenol from enzyme Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.17.3.2 0.0018
-
 xanthine
-
 Rattus norvegicus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.17.3.2 Iron iron-molybdenum protein Rattus norvegicus
1.17.3.2 Molybdenum an iron-molybdenum protein Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
1.17.3.2 Rattus norvegicus
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
1.17.3.2 additional information
-
 Rattus norvegicus
1.17.3.2 proteolytic modification
-
 Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.17.3.2 0.885
-
-
 Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.17.3.2 hypoxanthine + 2 H2O + 2 O2
-
 Rattus norvegicus urate + 2 H2O2
-
 ?
1.17.3.2 xanthine + H2O + O2 electron acceptor O2 Rattus norvegicus uric acid + H2O2
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.17.3.2 FAD flavoprotein Rattus norvegicus