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Literature summary extracted from

  • Parzen, S.D.; Fox, A.S.
    Purification of xanthine dehydrogenase from Drosophila melanogaster (1964), Biochim. Biophys. Acta, 92, 465-471.
    View publication on PubMed

General Stability

EC Number General Stability Organism
1.17.1.4 extremely labile Drosophila melanogaster

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.17.1.4 0.02
-
 hypoxanthine cosubstrate: NAD+ Drosophila melanogaster
1.17.1.4 0.02
-
 thio-NAD+ cosubstrate: hypoxanthine Drosophila melanogaster
1.17.1.4 0.0236
-
 xanthine cosubstrate: NAD+ Drosophila melanogaster
1.17.1.4 0.025
-
 NAD+ cosubstrate: hypoxanthine Drosophila melanogaster

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.17.1.4 hypoxanthine + NAD+ + H2O Drosophila melanogaster
-
 xanthine + NADH + H+
-
 ?
1.17.1.4 xanthine + NAD+ + H2O Drosophila melanogaster involved in pteridine metabolism, 40% of activity compared to hypoxanthine urate + NADH
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.17.1.4 Drosophila melanogaster
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.17.1.4 529fold purification, several (NH4)2SO4 precipitation steps Drosophila melanogaster

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.17.1.4 whole body
-
 Drosophila melanogaster
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.17.1.4 1328
-
-
 Drosophila melanogaster

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.17.1.4 hypoxanthine + NAD+ + H2O
-
 Drosophila melanogaster xanthine + NADH + H+
-
 ?
1.17.1.4 hypoxanthine + thio-NAD+ + H2O
-
 Drosophila melanogaster xanthine + thio-NADH
-
 ?
1.17.1.4 xanthine + NAD+ + H2O involved in pteridine metabolism, 40% of activity compared to hypoxanthine Drosophila melanogaster urate + NADH
-
 ?
1.17.1.4 xanthine + thio-NAD+ + H2O
-
 Drosophila melanogaster urate + thio-NADH
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.17.1.4 8
-
-
 Drosophila melanogaster

Cofactor

EC Number Cofactor Comment Organism Structure
1.17.1.4 NAD+
-
 Drosophila melanogaster