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Literature summary extracted from

  • Truglio, J.J.; Theis, K.; Leimkuhler, S.; Rappa, R.; Rajagopalan, K.V.; Kisker, C.
    Crystal structures of the active and alloxanthine-inhibited forms of xanthine dehydrogenase from Rhodobacter capsulatus (2002), Structure, 10, 115-125.
    View publication on PubMed

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
1.17.1.4 2.7 A resolution, direct coordination of alloxanthine to the molybdenum via a nitrogen atom Rhodobacter capsulatus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.17.1.4 4-hydroxypyrazolo(3,4-d)pyrimidine i.e. allopurinol; inhibition by direct coordination of the reaction product alloxanthine, to the molybdenum via a nitrogen atom Rhodobacter capsulatus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.17.1.4 hypoxanthine + NAD+ + H2O Rhodobacter capsulatus
-
 xanthine + NADH + H+
-
 ?
1.17.1.4 xanthine + NAD+ + H2O Rhodobacter capsulatus
-
 urate + NADH
-
 ?
1.17.1.4 xanthine + O2 + H2O Rhodobacter capsulatus
-
 urate + O2- + 2 H+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.17.1.4 Rhodobacter capsulatus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.17.1.4 cell culture
-
 Rhodobacter capsulatus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.17.1.4 4-hydroxypyrazolo(3,4-d)pyrimidine + nitroblue tetrazolium + H2O i.e. allopurinol Rhodobacter capsulatus 4,6-dihydroxypyrazolo(3,4-d)pyrimidine + reduced nitroblue tetrazolium
-
 ?
1.17.1.4 hypoxanthine + NAD+ + H2O
-
 Rhodobacter capsulatus xanthine + NADH + H+
-
 ?
1.17.1.4 xanthine + NAD+ + H2O
-
 Rhodobacter capsulatus urate + NADH
-
 ?
1.17.1.4 xanthine + O2 + H2O
-
 Rhodobacter capsulatus urate + O2- + 2 H+
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.17.1.4 additional information
-
 Rhodobacter capsulatus