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Literature summary extracted from

  • Panus, P.C.; Burgess, B.; Freeman, B.A.
    Characterization of cultured alveolar epithelial cell xanthine dehydrogenase/oxidase (1991), Biochim. Biophys. Acta, 1091, 303-309.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.17.1.4 2-amino-4-hydroxy-pterin + NAD+ + H2O Rattus sp. i.e. pterin isoxanthopterin + NADH
-
 ?
1.17.1.4 2-amino-4-hydroxy-pterin + NAD+ + H2O Rattus sp. conversion of xanthine dehydrogenase to xanthine oxidase is strongly influenced by in vitro cell culture of alveolar epithelial cells isoxanthopterin + NADH
-
 ?
1.17.1.4 xanthine + O2 + H2O Rattus sp. toxic reactions of xanthine oxidase-derived radicals are critical factors in several mechanisms of tissue pathology urate + O2- + 2 H+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.17.1.4 Rattus sp.
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.17.1.4 cell culture alveolar type II cells Rattus sp.
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.17.1.4 2-amino-4-hydroxy-pterin + methylene blue + H2O
-
 Rattus sp. isoxanthopterin + reduced methylene blue
-
 ?
1.17.1.4 2-amino-4-hydroxy-pterin + NAD+ + H2O i.e. pterin Rattus sp. isoxanthopterin + NADH
-
 ?
1.17.1.4 2-amino-4-hydroxy-pterin + NAD+ + H2O conversion of xanthine dehydrogenase to xanthine oxidase is strongly influenced by in vitro cell culture of alveolar epithelial cells Rattus sp. isoxanthopterin + NADH
-
 ?
1.17.1.4 2-amino-4-hydroxypterin + NAD+ + H2O i.e. pterin Rattus sp. isoxanthopterin + NADH
-
 ?
1.17.1.4 2-amino-4-hydroxypterin + NAD+ + H2O conversion of xanthine dehydrogenase to xanthine oxidase is strongly influenced by in vitro cell culture of alveolar epithelial cells Rattus sp. isoxanthopterin + NADH
-
 ?
1.17.1.4 4-hydroxypyrazolo(3,4-d)pyrimidine + NAD+ + H2O i.e. allopurinol Rattus sp. 4,6-dihydroxypyrazolo(3,4-d)pyrimidine + NADH
-
 ?
1.17.1.4 xanthine + O2 + H2O toxic reactions of xanthine oxidase-derived radicals are critical factors in several mechanisms of tissue pathology Rattus sp. urate + O2- + 2 H+
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.17.1.4 NAD+
-
 Rattus sp.