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Literature summary extracted from

  • Stark, K.; Seubert, P.; Lynch, G.; Baudry, M.
    Proteolytic conversion of xanthine dehydrogenase to xanthine oxidase: Evidence against a role for calcium-activated protease (calpain) (1989), Biochem. Biophys. Res. Commun., 165, 858-864.
    View publication on PubMed

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.17.1.4 90000
-
 x * 140000, SDS-PAGE, trypsin-treated: x * 90000, SDS-PAGE, conversion of dehydrogenase to oxidase activity Rattus sp.
1.17.1.4 140000
-
 x * 140000, SDS-PAGE, trypsin-treated: x * 90000, SDS-PAGE, conversion of dehydrogenase to oxidase activity Rattus sp.

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.17.1.4 xanthine + NAD+ + H2O Rattus sp. trypsin treatment leads to a complete conversion of xanthine dehydrogenase to xanthine oxidase activity urate + NADH
-
 r

Organism

EC Number Organism UniProt Comment Textmining
1.17.1.4 Rattus sp.
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.17.1.4 to homogeneity, chromatography techniques Rattus sp.

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.17.1.4 liver
-
 Rattus sp.
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.17.1.4 xanthine + NAD+ + H2O trypsin treatment leads to a complete conversion of xanthine dehydrogenase to xanthine oxidase activity Rattus sp. urate + NADH
-
 r

Subunits

EC Number Subunits Comment Organism
1.17.1.4 ? x * 140000, SDS-PAGE, trypsin-treated: x * 90000, SDS-PAGE, conversion of dehydrogenase to oxidase activity Rattus sp.

Cofactor

EC Number Cofactor Comment Organism Structure
1.17.1.4 NAD+
-
 Rattus sp.
1.17.1.4 NADH
-
 Rattus sp.