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Literature summary extracted from

  • Broquist, H.P.
    Homoisocitric Dehydrogenase (1971), Methods Enzymol., 17B, 118-119.
No PubMed abstract available

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.87 1.4
-
 homoisocitric acid
-
 Saccharomyces cerevisiae

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.1.1.87 Mg2+ required Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.87 1-hydroxy-1,2,4-butanetricarboxylate + NAD+ Saccharomyces cerevisiae
-
 2-oxoadipate + CO2 + NADH
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.87 Saccharomyces cerevisiae
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.87 partial Saccharomyces cerevisiae

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.87 1-hydroxy-1,2,4-butanetricarboxylate + NAD+
-
 Saccharomyces cerevisiae 2-oxoadipate + CO2 + NADH
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.87 7.8
-
 homocitrate + NAD+ Saccharomyces cerevisiae

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.87 NAD+ NADP+ can replace NAD+ Saccharomyces cerevisiae
1.1.1.87 NADP+ NADP+ can replace NAD+ Saccharomyces cerevisiae