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Literature summary extracted from
- Renal leukotriene C4 synthase: characterization, partial purification and alterations in experimental glomerulonephritis (1995), Biochim. Biophys. Acta, 1254, 207-215.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.4.1.20 | MK-0591 | - |
Rattus norvegicus |  |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 4.4.1.20 | 0.056 | - |
leukotriene A4 | pH 7.4, 25°C | Rattus norvegicus | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 4.4.1.20 | Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 4.4.1.20 | partial | Rattus norvegicus |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 4.4.1.20 | kidney | - |
Rattus norvegicus | - |
| 4.4.1.20 | liver | enzyme activity is significantly altered during the development of nephrotic serum nephritis, alterations occur during the initial inflammatory phase of the disease | Rattus norvegicus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.4.1.20 | leukotriene A4 + glutathione | - |
Rattus norvegicus | leukotriene C4 + H2O | - |
? | |
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