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Literature summary extracted from

  • Bach, M.K.; Brashler, J.R.; Morton, D.R.
    Solubilization and characterization of the leukotriene C4 synthetase of rat basophil leukemia cells: a novel, particulate glutathione S-transferase (1984), Arch. Biochem. Biophys., 230, 455-465.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
4.4.1.20 17-beta-estradiol-3-sulfate stimulates Rattus norvegicus
4.4.1.20 17-beta-estradiol-3-sulfate-17 glucuronide stimulates Rattus norvegicus
4.4.1.20 estriol-3-sulfate stimulates Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.4.1.20 estrone-3-sulfate IC50: 1.9 mM Rattus norvegicus
4.4.1.20 p-aminohippuric acid IC50: 0.26 mM Rattus norvegicus
4.4.1.20 probenecid IC50: 17 mM Rattus norvegicus
4.4.1.20 Sulfobromophthalein IC50: 0.06 mM Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.4.1.20 0.21
-
 leukotriene A4 pH 6.5, 30°C Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
4.4.1.20 particle-bound
-
 Rattus norvegicus
-
-

Organism

EC Number Organism UniProt Comment Textmining
4.4.1.20 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.4.1.20 basophilic leukemia cell line
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.4.1.20 leukotriene A4 + glutathione
-
 Rattus norvegicus leukotriene C4 + H2O
-
 ?

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
4.4.1.20 0.06
-
 IC50: 0.06 mM Rattus norvegicus Sulfobromophthalein
4.4.1.20 0.26
-
 IC50: 0.26 mM Rattus norvegicus p-aminohippuric acid
4.4.1.20 1.9
-
 IC50: 1.9 mM Rattus norvegicus estrone-3-sulfate
4.4.1.20 17
-
 IC50: 17 mM Rattus norvegicus probenecid