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Literature summary extracted from

  • Lam, B.K.; Penrose, J.F.; Rokach, J.; Xu, K.; Baldasaro, M.H.; Austen, K.F.
    Molecular cloning, expression and characterization of mouse leukotriene C4 synthase (1996), Eur. J. Biochem., 238, 606-612.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.4.1.20 COS-7 cells transfected with either human or cloned mouse leukotriene C4 synthase cDNA by DEAE-dextran transfection Mus musculus
4.4.1.20 COS-7 cells transfected with either human or cloned mouse leukotriene C4 synthase cDNA by DEAE-dextran transfection Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.4.1.20 MK-886 IC50: 0.0027 mM Homo sapiens
4.4.1.20 MK-886 IC50: 0.0031 mM Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
4.4.1.20 Homo sapiens
-
-
-
4.4.1.20 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.4.1.20 brain
-
 Mus musculus
-
4.4.1.20 heart
-
 Mus musculus
-
4.4.1.20 heart
-
 Homo sapiens
-
4.4.1.20 kidney
-
 Mus musculus
-
4.4.1.20 kidney
-
 Homo sapiens
-
4.4.1.20 lung
-
 Mus musculus
-
4.4.1.20 lung
-
 Homo sapiens
-
4.4.1.20 mast cell bone-marrow-derived Mus musculus
-
4.4.1.20 pancreas
-
 Homo sapiens
-
4.4.1.20 placenta
-
 Homo sapiens
-
4.4.1.20 skeletal muscle
-
 Mus musculus
-
4.4.1.20 skeletal muscle
-
 Homo sapiens
-
4.4.1.20 spleen slight Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.4.1.20 leukotriene A4 + glutathione
-
 Mus musculus leukotriene C4 + H2O
-
 ?
4.4.1.20 leukotriene A4 + glutathione
-
 Homo sapiens leukotriene C4 + H2O
-
 ?

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
4.4.1.20 0.0027
-
 IC50: 0.0027 mM Homo sapiens MK-886
4.4.1.20 0.0031
-
 IC50: 0.0031 mM Mus musculus MK-886