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Literature summary extracted from

  • Soberman, R.J.
    Purification and properties of leukotriene C4 synthase from guinea pig lung microsomes (1990), Methods Enzymol., 187, 335-337.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.4.1.20 leukotriene C4 IC50: 0.0021 mM, inhibits reaction with leukotriene C4 methyl ester Cavia porcellus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.4.1.20 0.015
-
 leukotriene A4 methyl ester 22°C, pH 7.6 Cavia porcellus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
4.4.1.20 microsome
-
 Cavia porcellus
-
-

Organism

EC Number Organism UniProt Comment Textmining
4.4.1.20 Cavia porcellus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.4.1.20
-
 Cavia porcellus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.4.1.20 lung
-
 Cavia porcellus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.4.1.20 leukotriene A4 + glutathione
-
 Cavia porcellus leukotriene C4 + H2O
-
 ?
4.4.1.20 leukotriene A4 methyl ester + glutathione
-
 Cavia porcellus leukotriene C4 methyl ester + H2O
-
 ?
4.4.1.20 leukotriene A4 methyl ester + glutathione
-
 Cavia porcellus leukotriene C4 methyl ester
-
 ?

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
4.4.1.20 0.0021
-
 IC50: 0.0021 mM, inhibits reaction with leukotriene C4 methyl ester Cavia porcellus leukotriene C4