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Literature summary extracted from

  • Gupta, N.; Gresser, M.J.; Ford-Hutchinson, A.W.
    Kinetic mechanism of glutathione conjugation to leukotriene A4 by leukotriene C4 synthase (1998), Biochim. Biophys. Acta, 1391, 157-168.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.4.1.20 L-699,333 i.e. 2,[2-[1-(4-chlorobenzyl)-4-methyl-6-[(5-phenylpyridin-2-yl)methoxy]-4,5-dihydro-1H-thiopyrano[2,3,4-c,d]indol-2-yl]ethoxy]butanoic acid, reversible, competitive against glutathione and non-competitive against leukotriene A4 Homo sapiens
4.4.1.20 leukotriene A4 substrate inhibition Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.4.1.20 0.0004
-
 glutathione pH 7.4, 25°C Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
4.4.1.20 membrane bound to Homo sapiens 16020
-

Organism

EC Number Organism UniProt Comment Textmining
4.4.1.20 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.4.1.20
-
 Homo sapiens

Reaction

EC Number Reaction Comment Organism Reaction ID
4.4.1.20 leukotriene C4 = leukotriene A4 + glutathione random rapid equilibrium mechanism Homo sapiens
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.4.1.20 leukotriene A4 + glutathione
-
 Homo sapiens leukotriene C4 + H2O
-
 ?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
4.4.1.20 0.0023
-
 leukotriene A4 pH 7.4, 25°C Homo sapiens