Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Cheong, C.G.; Bauer, C.B.; Brushaber, K.R.; Escalante-Semerena, J.C.; Rayment, I.
    Three-dimensional structure of the L-threonine-O-3-phosphate decarboxylase (CobD) enzyme from Salmonella enterica (2002), Biochemistry, 41, 4798-4808.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.1.1.81 overproduced in Escherichia coli Salmonella enterica

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
4.1.1.81 crystals grown from hanging drops, CobD crystallizes in orthorhombic space group I222, unit cell dimensions a = 67.96 A, b = 101.55 A, and c = 117.23 A Salmonella enterica

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
4.1.1.81 40800
-
-
 Salmonella enterica

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.1.1.81 L-threonine O-3-phosphate Salmonella enterica
-
 (R)-1-aminopropan-2-yl phosphate + CO2
-
 ?
4.1.1.81 L-threonine O-3-phosphate Salmonella enterica biosynthetic pathway of cobalamin, essential cofactor for many living organisms, only synthesized de novo by bacteria and archaea (R)-1-aminopropan-2-yl phosphate + CO2 precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin ?
6.3.1.10 ATP + adenosylcobyric acid + (R)-1-aminopropan-2-ol Salmonella enterica
-
 ADP + phosphate + adenosylcobinamide
-
 ?
6.3.1.10 ATP + adenosylcobyric acid + (R)-1-aminopropan-2-yl phosphate Salmonella enterica
-
 ADP + phosphate + adenosylcobinamide phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.1.1.81 no activity in eukaryota
-
-
-
4.1.1.81 Salmonella enterica
-
-
-
6.3.1.10 Salmonella enterica
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.1.1.81
-
 Salmonella enterica

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.1.81 L-threonine O-3-phosphate
-
 Salmonella enterica (R)-1-aminopropan-2-yl phosphate + CO2
-
 ?
4.1.1.81 L-threonine O-3-phosphate biosynthetic pathway of cobalamin, essential cofactor for many living organisms, only synthesized de novo by bacteria and archaea Salmonella enterica (R)-1-aminopropan-2-yl phosphate + CO2 precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin ?
6.3.1.10 ATP + adenosylcobyric acid + (R)-1-aminopropan-2-ol
-
 Salmonella enterica ADP + phosphate + adenosylcobinamide
-
 ?
6.3.1.10 ATP + adenosylcobyric acid + (R)-1-aminopropan-2-yl phosphate
-
 Salmonella enterica ADP + phosphate + adenosylcobinamide phosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
4.1.1.81 dimer
-
 Salmonella enterica

Synonyms

EC Number Synonyms Comment Organism
4.1.1.81 CobD
-
 Salmonella enterica
4.1.1.81 CobD gene product
-
 Salmonella enterica