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Literature summary extracted from

  • Wright, M.M.; McMaster, C.R.
    PC and PE synthesis: mixed micellar analysis of the cholinephosphotransferase and ethanolaminephosphotransferase activities of human choline/ethanolamine phosphotransferase 1 (CEPT1) (2002), Lipids, 37, 663-672.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.8.1 chelerythrine protein kinase C inhibitor, IC50 0.04 mM Homo sapiens
2.7.8.1 R59949 human DAG kinase inhibitor, IC50 0.04 mM Homo sapiens
2.7.8.2 chelerythrine inhibitor of protein kinase C, IC50 0.04 mM Homo sapiens
2.7.8.2 R59949 inhibitor of protein kinase C, IC50 0.04 mM Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.8.1 0.036
-
 CDP-choline 25°C, pH 8.0 Homo sapiens
2.7.8.1 0.098
-
 CDP-ethanolamine 25°C, pH 8.0 Homo sapiens
2.7.8.2 0.036
-
 CDP-choline 25°C, pH 8.0 Homo sapiens
2.7.8.2 0.098
-
 CDP-ethanolamine 25°C, pH 8.0 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.7.8.1 Homo sapiens
-
 dual-specificity enzyme, activity of EC 2.7.8.1 and EC 2.7.8.2
-
2.7.8.2 Homo sapiens
-
 dual-specificity enzyme, activitiy of EC 2.7.8.1 and EC 2.7.8.2
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.8.1 CDP-choline + 1,2-diacylglycerol preferred substrates: di-18:1 diacylglycerol, di-16:1 diacylglycerol, 16:0/18:1 diacylglycerol Homo sapiens CMP + phosphatidylcholine
-
 ?
2.7.8.1 CDP-ethanolamine + 1,2-diacylglycerol preferred substrates: 16:0/18:1 diacylglycerol, di-18:1 diacylglycerol Homo sapiens CMP + a phosphatidylethanolamine
-
 ?
2.7.8.2 CDP-choline + 1,2-diacylglycerol preferred substrates: di-18:1-diacylglycerol, di-16:1-diacylglycerol, 16:0/18:1-diacylglycerol, 16:0/22:6-diacylglycerol Homo sapiens CMP + a phosphatidylcholine
-
 ?
2.7.8.2 CDP-ethanolamine + 1,2-diacylglycerol preferred substrates: 16:0/18:1 diacylglycerol, di-18:1 diacylglycerol, di-18:1 diacylglycerol Homo sapiens CMP + phosphatidylethanolamine
-
 ?

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.7.8.1 0.04
-
 protein kinase C inhibitor, IC50 0.04 mM Homo sapiens chelerythrine
2.7.8.1 0.04
-
 human DAG kinase inhibitor, IC50 0.04 mM Homo sapiens R59949
2.7.8.2 0.04
-
 inhibitor of protein kinase C, IC50 0.04 mM Homo sapiens R59949
2.7.8.2 0.04
-
 inhibitor of protein kinase C, IC50 0.04 mM Homo sapiens chelerythrine