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Literature summary extracted from

  • Renooij, W.; Snyder, F.
    Biosynthesis of 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet activating factor and a hypotensive lipid) by cholinephosphotransferase in various rat tissues (1981), Biochim. Biophys. Acta, 663, 545-556.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.8.2 dithiothreitol slight enhancement of activity towards 1-alkyl-2-acetyl-sn-glycerol, inhibition of activity towards diacylglycerol Rattus norvegicus

General Stability

EC Number General Stability Organism
2.7.8.2 dithiothreitol stabilizes Rattus norvegicus
2.7.8.2 no loss of activity by freezing and thawing one time Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.8.2 dithiothreitol slight enhancement of activity towards 1-alkyl-2-acetyl-sn-glycerol, inhibition of activity towards diacylglycerol Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.8.2 microsome
-
 Rattus norvegicus
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.8.2 Mg2+ required Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.8.2 additional information Rattus norvegicus last step in de novo synthesis of diacylglycerophosphocholine ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.8.2 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.8.2 kidney
-
 Rattus norvegicus
-
2.7.8.2 liver
-
 Rattus norvegicus
-
2.7.8.2 lung fetal Rattus norvegicus
-
2.7.8.2 spleen
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.8.2 CDP-choline + 1,2-diacylglycerol
-
 Rattus norvegicus CMP + a phosphatidylcholine
-
 ?
2.7.8.2 CDP-choline + 1-batyl-2-acetyl-sn-glycerol
-
 Rattus norvegicus CMP + 1-batyl-2-acetyl-sn-glycero-3-phosphocholine
-
 ?
2.7.8.2 CDP-choline + 1-chimyl-2-acetyl-sn-glycerol
-
 Rattus norvegicus CMP + 1-chimyl-2-acetyl-sn-glycero-3-phosphocholine
-
 ?
2.7.8.2 CDP-choline + 1-selachyl-2-acetyl-sn-glycerol
-
 Rattus norvegicus CMP + 1-selachyl-2-acetyl-sn-glycero-3-phosphocholine
-
 ?
2.7.8.2 additional information last step in de novo synthesis of diacylglycerophosphocholine Rattus norvegicus ?
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.8.2 37
-
 assay at Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.8.2 8
-
 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine Rattus norvegicus