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Literature summary extracted from
- Effects of antibiotics, N-acetylaminoacyl-tRNA and other agents on the elongation-factor Tu dependent and ribosome-dependent GTP hydrolysis promoted by 2'(3')-O-L-phenylalanyladenosine (1981), Eur. J. Biochem., 117, 27-31.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.6.5.3 | bluensomycin | - |
Escherichia coli |  |
| 3.6.5.3 | gentamicin C1 | - |
Escherichia coli | |
| 3.6.5.3 | gentamicin C1a | - |
Escherichia coli | |
| 3.6.5.3 | hygromycin | - |
Escherichia coli | |
| 3.6.5.3 | kanamycin A | - |
Escherichia coli | |
| 3.6.5.3 | kanamycin B | - |
Escherichia coli | |
| 3.6.5.3 | neomycin C | - |
Escherichia coli | |
| 3.6.5.3 | paromycin | - |
Escherichia coli | |
| 3.6.5.3 | sisomicin | - |
Escherichia coli | |
| 3.6.5.3 | streptomycin | - |
Escherichia coli | |
| 3.6.5.3 | tobramycin | - |
Escherichia coli | |
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 3.6.5.3 | medicine | protein biosynthesis | Escherichia coli |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.6.5.3 | chloramphenicol | - |
Escherichia coli | |
| 3.6.5.3 | dihydrostreptomycin | - |
Escherichia coli | |
| 3.6.5.3 | hygromycin A | - |
Escherichia coli | |
| 3.6.5.3 | N-ethylmaleimide | - |
Escherichia coli | |
| 3.6.5.3 | neamine | - |
Escherichia coli | |
| 3.6.5.3 | neomycin B | - |
Escherichia coli | |
| 3.6.5.3 | NH4Cl | at higher concentration | Escherichia coli | |
| 3.6.5.3 | ribostamycin | - |
Escherichia coli | |
| 3.6.5.3 | sparsomycin | - |
Escherichia coli | |
| 3.6.5.3 | streptogramin A | - |
Escherichia coli | |
| 3.6.5.3 | viomycin | - |
Escherichia coli | |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.6.5.3 | Mg2+ | - |
Escherichia coli | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.6.5.3 | GTP + H2O | Escherichia coli | - |
GDP + phosphate | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.6.5.3 | Escherichia coli | - |
elongations factor (EF)Tu | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.6.5.3 | GTP + H2O | - |
Escherichia coli | GDP + phosphate | - |
? | |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 3.6.5.3 | 30 | - |
- |
Escherichia coli |
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Release 2023.1 (January 2023)
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