Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Hall, A.
    Rho GTPases and the actin cytoskeleton (1998), Science, 279, 509-514.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.6.5.2 Cdc42 activation of Rac Saccharomyces cerevisiae
3.6.5.2 GTPase activating protein GAP
-
 Homo sapiens
3.6.5.2 GTPase activating protein GAP
-
 Saccharomyces cerevisiae
3.6.5.2 guanine nucleotide exchange factor GEF activation of RhoGTPases through direct protein-protein interaction Homo sapiens
3.6.5.2 guanine nucleotide exchange factor GEF activation of RhoGTPases through direct protein-protein interaction Saccharomyces cerevisiae
3.6.5.2 Insulin activation of Rac, assembly of actin filaments Homo sapiens
3.6.5.2 lysophosphatidic acid activation of Rho, assembly of contractile actin-myosin filaments and focal adhesion complexes Saccharomyces cerevisiae
3.6.5.2 platelet derived growth factor Rac activation, assembly of actin filaments Homo sapiens
3.6.5.2 Rac activation of Rho, cross-talk between Ras- and Rho subfamilies Saccharomyces cerevisiae
3.6.5.2 Ras cross-talk between Ras- and Rho subfamilies, activation of Rac Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.6.5.2 guanine nucleotide dissociation inhibitor GDI down-regulating GTPase activity, inhibition of nucleotide dissociation Homo sapiens
3.6.5.2 guanine nucleotide dissociation inhibitor GDI down-regulating GTPase activity, inhibition of nucleotide dissociation Saccharomyces cerevisiae

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.6.5.2 cytosol Rho GTPase, partially cytosolic in association with guanine nucleotide dissociation inhibitor Saccharomyces cerevisiae 5829
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.6.5.2 GTP + H2O Homo sapiens
-
 GDP + phosphate
-
 ir
3.6.5.2 GTP + H2O Saccharomyces cerevisiae
-
 GDP + phosphate
-
 ir

Organism

EC Number Organism UniProt Comment Textmining
3.6.5.2 Homo sapiens
-
-
-
3.6.5.2 Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.6.5.2 GTP + H2O
-
 Homo sapiens GDP + phosphate
-
 ir
3.6.5.2 GTP + H2O
-
 Saccharomyces cerevisiae GDP + phosphate
-
 ir

Subunits

EC Number Subunits Comment Organism
3.6.5.2 heteromer
-
 Saccharomyces cerevisiae

Synonyms

EC Number Synonyms Comment Organism
3.6.5.2 Cdc42 Rho subfamily Homo sapiens
3.6.5.2 Cdc42 Rho subfamily Saccharomyces cerevisiae
3.6.5.2 Cdc42Hs Rho subfamily Homo sapiens
3.6.5.2 Rac1 Rho subfamily Homo sapiens
3.6.5.2 Rac1 Rho subfamily Saccharomyces cerevisiae
3.6.5.2 Ran
-
 Homo sapiens
3.6.5.2 RhoA Rho subfamily Homo sapiens
3.6.5.2 RhoA Rho subfamily Saccharomyces cerevisiae