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Literature summary extracted from

  • Rawson, R.; Zelenski, N.; Nijhawan, D.; Ye, J.; Sakai, J.; Hasan, M.; Chang, T.; Brown, M.; Goldstein, J.
    Complementation cloning of S2P, a gene encoding a putative metalloprotease required for intramembrane cleavage of SREBPs (1997), Mol. Cell, 1, 47-57.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.24.85 expressed in CHO cell line Cricetulus griseus
3.4.24.85 expressed in M19 cell line Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
3.4.24.85 additional information M19 mutant cell line of CHO-K1 cells with no s2p activity Cricetulus griseus
3.4.24.85 additional information mutants in any of the histidines for phenylalanine or glutamic acid for alanine of the consensus metal-binding site abolished activity Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.85 Cricetulus griseus O54862 Chinese hamster, s2p cloned
-
3.4.24.85 Homo sapiens O43462 s2p cloned
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.24.85 HeLa cell cDNA library Homo sapiens
-
3.4.24.85 ovary cell line CHO-7 and M19 S2P deficient cell lines Cricetulus griseus
-

Cofactor

EC Number Cofactor Comment Organism Structure
3.4.24.85 Zn zinc metalloprotease Homo sapiens