Literature summary extracted from
Rawson, R.; Zelenski, N.; Nijhawan, D.; Ye, J.; Sakai, J.; Hasan, M.; Chang, T.; Brown, M.; Goldstein, J.
Complementation cloning of S2P, a gene encoding a putative metalloprotease required for intramembrane cleavage of SREBPs (1997), Mol. Cell, 1, 47-57.
Cloned(Commentary)
EC Number |
Cloned (Comment) |
Organism |
---|
3.4.24.85 |
expressed in CHO cell line |
Cricetulus griseus |
3.4.24.85 |
expressed in M19 cell line |
Homo sapiens |
Protein Variants
EC Number |
Protein Variants |
Comment |
Organism |
---|
3.4.24.85 |
additional information |
M19 mutant cell line of CHO-K1 cells with no s2p activity |
Cricetulus griseus |
3.4.24.85 |
additional information |
mutants in any of the histidines for phenylalanine or glutamic acid for alanine of the consensus metal-binding site abolished activity |
Homo sapiens |
Organism
EC Number |
Organism |
UniProt |
Comment |
Textmining |
---|
3.4.24.85 |
Cricetulus griseus |
O54862 |
Chinese hamster, s2p cloned |
- |
3.4.24.85 |
Homo sapiens |
O43462 |
s2p cloned |
- |
Source Tissue
EC Number |
Source Tissue |
Comment |
Organism |
Textmining |
---|
3.4.24.85 |
HeLa cell |
cDNA library |
Homo sapiens |
- |
3.4.24.85 |
ovary cell line |
CHO-7 and M19 S2P deficient cell lines |
Cricetulus griseus |
- |
Cofactor
EC Number |
Cofactor |
Comment |
Organism |
Structure |
---|
3.4.24.85 |
Zn |
zinc metalloprotease |
Homo sapiens |
|