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Literature summary extracted from

  • Asai, M.; Hattori, C.; Szabo, B.; Sasagawa, N.; Maruyama, K.; Tanuma, S.I.; Ishiura, S.
    Putative function of ADAM9, ADAM10, and ADAM17 as APP alpha-secretase (2003), Biochem. Biophys. Res. Commun., 301, 231-235.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.24.B9 expression in COS-7 cells and in human glioblastoma A172 cells Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.24.B9 membrane anchored on the cell surface Homo sapiens 16020
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.24.B9 amyloid precursor protein + H2O Homo sapiens enzyme shows alpha-secretase activity, the alpha-secretase might be composed of several ADAM enzymes in a complexe ?
-
 ?
3.4.24.B9 proteins + H2O Homo sapiens
-
 peptides
-
 ?
3.4.24.81 beta-amyloid precursor protein Homo sapiens A172 cell line has alpha-secretase activity sAPP-alpha fragment + C-terminal fragment
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.B9 Homo sapiens
-
-
-
3.4.24.81 Homo sapiens
-
 cell line
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.24.B9 A-172 cell
-
 Homo sapiens
-
3.4.24.B9 brain
-
 Homo sapiens
-
3.4.24.81 A-172 cell A-172 cell line has potent alpha-secretase activity, higher than HEK-293 cell line Homo sapiens
-
3.4.24.81 bone marrow there is expression of the enzyme Homo sapiens
-
3.4.24.81 brain there is expression of the enzyme Homo sapiens
-
3.4.24.81 kidney cell line there is expression of the enzyme Homo sapiens
-
3.4.24.81 liver there is expression of the enzyme Homo sapiens
-
3.4.24.81 lymph node there is expression of the enzyme Homo sapiens
-
3.4.24.81 spleen there is expression of the enzyme Homo sapiens
-
3.4.24.81 thymus there is expression of the enzyme Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.B9 amyloid precursor protein + H2O enzyme shows alpha-secretase activity Homo sapiens ?
-
 ?
3.4.24.B9 amyloid precursor protein + H2O enzyme shows alpha-secretase activity, the alpha-secretase might be composed of several ADAM enzymes in a complexe Homo sapiens ?
-
 ?
3.4.24.B9 proteins + H2O
-
 Homo sapiens peptides
-
 ?
3.4.24.81 beta-amyloid precursor protein A172 cell line has alpha-secretase activity Homo sapiens sAPP-alpha fragment + C-terminal fragment
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.24.B9 ADAM9
-
 Homo sapiens
3.4.24.B9 M12.209 Merops-ID Homo sapiens