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Literature summary extracted from

  • Kovachy, R.J.; Copley, S.D.; Allen, R.H.
    Recognition, isolation, and characterization of rat liver D-methylmalonyl coenzyme A hydrolase (1983), J. Biol. Chem., 258, 11415-11421.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.2.17 acetyl-CoA competitive inhibition Rattus norvegicus
3.1.2.17 butyryl-CoA competitive Rattus norvegicus
3.1.2.17 CoA competitive inhibition Rattus norvegicus
3.1.2.17 decanoyl-CoA noncompetitive inhibition Rattus norvegicus
3.1.2.17 glutaryl-CoA competitive inhibition Rattus norvegicus
3.1.2.17 heptanoyl-CoA competitive inhibition Rattus norvegicus
3.1.2.17 hexanoyl-CoA competitive inhibition Rattus norvegicus
3.1.2.17 malonyl-CoA competitive inhibition Rattus norvegicus
3.1.2.17 nonanoyl-CoA noncompetitive inhibition Rattus norvegicus
3.1.2.17 octanoyl-CoA noncompetitive inhibition Rattus norvegicus
3.1.2.17 palmitoyl-CoA noncompetitive inhibition Rattus norvegicus
3.1.2.17 pentanoyl-CoA competitive inhibition Rattus norvegicus
3.1.2.17 propionyl-CoA competitive inhibition Rattus norvegicus
3.1.2.17 succinyl-CoA competitive inhibition Rattus norvegicus
3.1.2.17 tridecanoyl-CoA noncompetitive inhibition Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.2.17 0.7
-
malonyl-CoA pH 6.0, 30°C Rattus norvegicus
3.1.2.17 0.7
-
(S)-methylmalonyl-CoA pH 6.0, 30°C Rattus norvegicus
3.1.2.17 1.4
-
DL-methylmalonyl-CoA pH 6.0, 30°C Rattus norvegicus
3.1.2.17 1.9
-
propionyl-CoA pH 6.0, 30°C Rattus norvegicus
3.1.2.17 14
-
acetyl-CoA pH 6.0, 30°C Rattus norvegicus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.1.2.17 35000
-
gel filtration Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.2.17 (S)-methylmalonyl-CoA + H2O Rattus norvegicus
-
methylmalonate + CoA
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.1.2.17 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.1.2.17 partially Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.2.17 liver
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.1.2.17 1.41
-
-
Rattus norvegicus

Storage Stability

EC Number Storage Stability Organism
3.1.2.17 -20°C, purified enzyme stable for at least 1 month Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.2.17 (S)-methylmalonyl-CoA + H2O
-
Rattus norvegicus methylmalonate + CoA
-
?
3.1.2.17 (S)-methylmalonyl-CoA + H2O not active on the L-isomer Rattus norvegicus methylmalonate + CoA
-
?
3.1.2.17 acetyl-CoA + H2O
-
Rattus norvegicus CoA + acetate
-
?
3.1.2.17 DL-methylmalonyl-CoA + H2O
-
Rattus norvegicus CoA + methylmalonate
-
?
3.1.2.17 malonyl-CoA + H2O 16% of the activity with (S)-methylmalonyl-CoA Rattus norvegicus malonate + CoA
-
?
3.1.2.17 additional information acetyl-CoA 1% of the activity with (S)-methylmalonyl-CoA , succinyl-CoA and palmitoyl-CoA hydrolyzed at less than 1% of the activity with (S)-methylmalonyl-CoA Rattus norvegicus ?
-
?
3.1.2.17 propionyl-CoA + H2O 3% of the activity with (S)-methylmalonyl-CoA Rattus norvegicus propionate + CoA
-
?

Subunits

EC Number Subunits Comment Organism
3.1.2.17 monomer 1 * 35000, SDS-PAGE, in absence and presence of 1% 2-mercaptoethanol Rattus norvegicus

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
3.1.2.17 23.3
-
(S)-methylmalonyl-CoA pH 6.0, 30°C Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.2.17 6
-
50% activity at pH 5.3 and pH 7.1 Rattus norvegicus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.1.2.17 0.01
-
palmitoyl-CoA pH 6.0, 30°C Rattus norvegicus
3.1.2.17 0.04
-
tridecanoyl-CoA pH 6.0, 30°C Rattus norvegicus
3.1.2.17 0.05
-
decanoyl-CoA pH 6.0, 30°C Rattus norvegicus
3.1.2.17 0.2
-
nonanoyl-CoA pH 6.0, 30°C Rattus norvegicus
3.1.2.17 0.5
-
octanoyl-CoA pH 6.0, 30°C Rattus norvegicus
3.1.2.17 0.6
-
malonyl-CoA pH 6.0, 30°C Rattus norvegicus
3.1.2.17 1.4
-
CoA pH 6.0, 30°C Rattus norvegicus
3.1.2.17 1.5
-
succinyl-CoA pH 6.0, 30°C Rattus norvegicus
3.1.2.17 1.5
-
heptanoyl-CoA pH 6.0, 30°C Rattus norvegicus
3.1.2.17 1.7
-
hexanoyl-CoA pH 6.0, 30°C Rattus norvegicus
3.1.2.17 2.6
-
butyryl-CoA pH 6.0, 30°C Rattus norvegicus
3.1.2.17 2.6
-
valeryl-CoA pH 6.0, 30°C Rattus norvegicus
3.1.2.17 3
-
propionyl-CoA pH 6.0, 30°C Rattus norvegicus
3.1.2.17 4.1
-
acetyl-CoA pH 6.0, 30°C Rattus norvegicus
3.1.2.17 4.9
-
glutaryl-CoA pH 6.0, 30°C Rattus norvegicus