Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Bambara, R.A.; Jessee, C.B.
    Properties of DNA polymerases delta and epsilon, and their roles in eukaryotic DNA replication (1991), Biochim. Biophys. Acta, 1088, 11-24.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.7.7 dimethyl sulfoxide stimulates DNA polymerase alpha and delta, inhibits human DNA polymerase epsilon Mammalia
2.7.7.7 dimethyl sulfoxide stimulates DNA polymerase alpha and delta, inhibits human DNA polymerase epsilon Mus musculus
2.7.7.7 dimethyl sulfoxide stimulates DNA polymerase alpha and delta, inhibits human DNA polymerase epsilon Homo sapiens
2.7.7.7 dimethyl sulfoxide stimulates DNA polymerase alpha and delta, inhibits human DNA polymerase epsilon Bos taurus
2.7.7.7 dimethyl sulfoxide stimulates DNA polymerase alpha and delta, inhibits human DNA polymerase epsilon Oryctolagus cuniculus
2.7.7.7 proliferating cell nuclear antigen PCNA, specific auxiliary factor stimulating DNA polymerase delta Mammalia
2.7.7.7 proliferating cell nuclear antigen PCNA, specific auxiliary factor stimulating DNA polymerase delta Mus musculus
2.7.7.7 proliferating cell nuclear antigen PCNA, specific auxiliary factor stimulating DNA polymerase delta Homo sapiens
2.7.7.7 proliferating cell nuclear antigen PCNA, specific auxiliary factor stimulating DNA polymerase delta Bos taurus
2.7.7.7 proliferating cell nuclear antigen PCNA, specific auxiliary factor stimulating DNA polymerase delta Oryctolagus cuniculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.7.7 2-(p-n-Butylanilino)-2'-deoxyadenosine 5'-triphosphate inhibition of DNA polymerase alpha at 100fold lower concentration than DNA polymerase delta Bos taurus
2.7.7.7 2-(p-n-Butylanilino)-2'-deoxyadenosine 5'-triphosphate inhibition of DNA polymerase alpha at 100fold lower concentration than DNA polymerase delta Homo sapiens
2.7.7.7 2-(p-n-Butylanilino)-2'-deoxyadenosine 5'-triphosphate inhibition of DNA polymerase alpha at 100fold lower concentration than DNA polymerase delta Mammalia
2.7.7.7 2-(p-n-Butylanilino)-2'-deoxyadenosine 5'-triphosphate inhibition of DNA polymerase alpha at 100fold lower concentration than DNA polymerase delta Mus musculus
2.7.7.7 2-(p-n-Butylanilino)-2'-deoxyadenosine 5'-triphosphate inhibition of DNA polymerase alpha at 100fold lower concentration than DNA polymerase delta Oryctolagus cuniculus
2.7.7.7 aphidicolin DNA polymerase alpha; DNA polymerase delta; DNA polymerase epsilon Bos taurus
2.7.7.7 aphidicolin DNA polymerase alpha; DNA polymerase delta; DNA polymerase epsilon Homo sapiens
2.7.7.7 aphidicolin DNA polymerase alpha; DNA polymerase delta; DNA polymerase epsilon Mammalia
2.7.7.7 aphidicolin DNA polymerase alpha; DNA polymerase delta; DNA polymerase epsilon Mus musculus
2.7.7.7 aphidicolin DNA polymerase alpha; DNA polymerase delta; DNA polymerase epsilon Oryctolagus cuniculus
2.7.7.7 aphidicolin
-
 Saccharomyces cerevisiae
2.7.7.7 Carbonyldiphosphonate polymerase delta and epsilon Bos taurus
2.7.7.7 Carbonyldiphosphonate
-
 Homo sapiens
2.7.7.7 Carbonyldiphosphonate
-
 Mammalia
2.7.7.7 Carbonyldiphosphonate
-
 Mus musculus
2.7.7.7 Carbonyldiphosphonate
-
 Oryctolagus cuniculus
2.7.7.7 Dideoxynucleoside 5'-triphosphate polymerase epsilon, slightly sensitive Bos taurus
2.7.7.7 Dideoxynucleoside 5'-triphosphate polymerase epsilon, slightly sensitive Homo sapiens
2.7.7.7 Dideoxynucleoside 5'-triphosphate polymerase epsilon, slightly sensitive Mammalia
2.7.7.7 Dideoxynucleoside 5'-triphosphate polymerase epsilon, slightly sensitive Mus musculus
2.7.7.7 Dideoxynucleoside 5'-triphosphate polymerase epsilon, slightly sensitive Oryctolagus cuniculus
2.7.7.7 dimethyl sulfoxide stimulates DNA polymerase alpha and delta, inhibits human DNA polymerase epsilon Homo sapiens
2.7.7.7 N2-(p-n-butylphenyl)-2'-deoxyguanosine 5'-triphosphate inhibition of DNA polymerase alpha at 100fold; lower concentration than DNA polymerase delta Bos taurus
2.7.7.7 N2-(p-n-butylphenyl)-2'-deoxyguanosine 5'-triphosphate inhibition of DNA polymerase alpha at 100fold; lower concentration than DNA polymerase delta Homo sapiens
2.7.7.7 N2-(p-n-butylphenyl)-2'-deoxyguanosine 5'-triphosphate inhibition of DNA polymerase alpha at 100fold; lower concentration than DNA polymerase delta Mammalia
2.7.7.7 N2-(p-n-butylphenyl)-2'-deoxyguanosine 5'-triphosphate inhibition of DNA polymerase alpha at 100fold; lower concentration than DNA polymerase delta Mus musculus
2.7.7.7 N2-(p-n-butylphenyl)-2'-deoxyguanosine 5'-triphosphate inhibition of DNA polymerase alpha at 100fold; lower concentration than DNA polymerase delta Oryctolagus cuniculus
2.7.7.7 N2-(p-n-butylphenyl)-2'-deoxyguanosine 5'-triphosphate
-
 Saccharomyces cerevisiae

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.7.7 48000
-
 x * 180000 + x * 86000 + x * 58000 + x * 48000, polymerase alpha Saccharomyces cerevisiae
2.7.7.7 49000
-
 x * 60000 + x * 49000, SDS-PAGE Bos taurus
2.7.7.7 50000
-
 1 * 125000 + 1 * 50000, DNA polymerase delta Mus musculus
2.7.7.7 55000
-
 x * 125000 + x * 55000, polymerase delta Saccharomyces cerevisiae
2.7.7.7 58000
-
 x * 180000 + x * 86000 + x * 58000 + x * 48000, polymerase alpha Saccharomyces cerevisiae
2.7.7.7 60000
-
 x * 60000 + x * 49000, SDS-PAGE Bos taurus
2.7.7.7 86000
-
 x * 180000 + x * 86000 + x * 58000 + x * 48000, polymerase alpha Saccharomyces cerevisiae
2.7.7.7 122000
-
 DNA polymerase epsilon, gel filtration Oryctolagus cuniculus
2.7.7.7 125000
-
 x * 125000 + x * 55000, polymerase delta Saccharomyces cerevisiae
2.7.7.7 125000
-
 1 * 125000 + 1 * 50000, DNA polymerase delta Mus musculus
2.7.7.7 170000
-
-
 Saccharomyces cerevisiae
2.7.7.7 170000
-
-
 Bos taurus
2.7.7.7 170000
-
 DNA polymerase epsilon Homo sapiens
2.7.7.7 178000
-
 DNA polymerase delta Mus musculus
2.7.7.7 180000
-
 x * 180000 + x * 86000 + x * 58000 + x * 48000, polymerase alpha Saccharomyces cerevisiae
2.7.7.7 200000
-
 polymerase delta, gel filtration Bos taurus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.7.7 deoxynucleoside triphosphate + DNAn Mammalia
-
 diphosphate + DNAn+1
-
 ?
2.7.7.7 deoxynucleoside triphosphate + DNAn Mus musculus
-
 diphosphate + DNAn+1
-
 ?
2.7.7.7 deoxynucleoside triphosphate + DNAn Homo sapiens
-
 diphosphate + DNAn+1
-
 ?
2.7.7.7 deoxynucleoside triphosphate + DNAn Saccharomyces cerevisiae
-
 diphosphate + DNAn+1
-
 ?
2.7.7.7 deoxynucleoside triphosphate + DNAn Bos taurus
-
 diphosphate + DNAn+1
-
 ?
2.7.7.7 deoxynucleoside triphosphate + DNAn Oryctolagus cuniculus
-
 diphosphate + DNAn+1
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.7 Bos taurus
-
-
-
2.7.7.7 Homo sapiens
-
-
-
2.7.7.7 Mammalia
-
-
-
2.7.7.7 Mus musculus
-
-
-
2.7.7.7 Oryctolagus cuniculus
-
-
-
2.7.7.7 Saccharomyces cerevisiae
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.7.7 bone marrow
-
 Oryctolagus cuniculus
-
2.7.7.7 placenta
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.7 deoxynucleoside triphosphate + DNAn
-
 Mammalia diphosphate + DNAn+1
-
 ?
2.7.7.7 deoxynucleoside triphosphate + DNAn
-
 Mus musculus diphosphate + DNAn+1
-
 ?
2.7.7.7 deoxynucleoside triphosphate + DNAn
-
 Homo sapiens diphosphate + DNAn+1
-
 ?
2.7.7.7 deoxynucleoside triphosphate + DNAn
-
 Saccharomyces cerevisiae diphosphate + DNAn+1
-
 ?
2.7.7.7 deoxynucleoside triphosphate + DNAn
-
 Bos taurus diphosphate + DNAn+1
-
 ?
2.7.7.7 deoxynucleoside triphosphate + DNAn
-
 Oryctolagus cuniculus diphosphate + DNAn+1
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.7.7 ?
-
 Mammalia
2.7.7.7 ? x * 125000 + x * 55000, polymerase delta Saccharomyces cerevisiae
2.7.7.7 ? x * 180000 + x * 86000 + x * 58000 + x * 48000, polymerase alpha Saccharomyces cerevisiae
2.7.7.7 ? x * 60000 + x * 49000, SDS-PAGE Bos taurus
2.7.7.7 dimer
-
 Homo sapiens
2.7.7.7 dimer
-
 Saccharomyces cerevisiae
2.7.7.7 dimer
-
 Bos taurus
2.7.7.7 dimer 1 * 125000 + 1 * 50000, DNA polymerase delta Mus musculus
2.7.7.7 monomer
-
 Bos taurus
2.7.7.7 monomer 1 * 170000, DNA polymerase epsilon Homo sapiens