Literature summary extracted from

Callaci, S.; Heyduk, T.
Conformation and DNA binding properties of a single-stranded DNA binding region of sigma 70 subunit from Escherichia coli RNA polymerase are modulated by an interaction with the core enzyme (1998), Biochemistry, 37, 3312-3320.

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.7.7.6	Escherichia coli	-	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2.7.7.6	nucleoside triphosphate + RNAn	the enzyme requires DNA as template	Escherichia coli	diphosphate + RNAn+1	-	?

Subunits

EC Number	Subunits	Comment	Organism
2.7.7.6	More	binding of the sigma70 subunit to the core enzyme induces conformational changes in a single-stranded DNA binding region of the protein. As a consequence of these conformational changes, sigma70 subunit gains the specificity for the nontemplate strand of the melted region in the open complex	Escherichia coli

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Release 2023.1 (January 2023)