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Literature summary extracted from

  • Aphasizhev, R.; Aphasizheva, I.; Simpson, L.
    A tale of two TUTases (2003), Proc. Natl. Acad. Sci. USA, 100, 10617-10622.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.7.52 expression of RET2 in Leishmania tarentolae cells as cytosolic enzyme by removing the mitochondrial targeting signal sequence Trypanosoma brucei

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.7.52 additional information RNA interference, i.e. RNAi, induced by tetracyclines causes down-regulation of RET1 and RET2 expression in vitro and in vivo Trypanosoma brucei

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.7.52 additional information Trypanosoma brucei down-regulation of RET1, but not of RET2, affects length distribution of gRNA 3' oligo(U) tails ?
-
 ?
2.7.7.52 UTP + RNAn Trypanosoma brucei addition of non-coded poly(U) tail to gRNAs diphosphate + RNAn+1
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.52 Trypanosoma brucei
-
 RET1 and RET2, i.e. RNA editing TUTases 1 and 2, as components of different editing complexes
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.7.52 recombinant TAP-tagged enzyme from Leishmania tarentolae cells Trypanosoma brucei

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.52 additional information down-regulation of RET1, but not of RET2, affects length distribution of gRNA 3' oligo(U) tails Trypanosoma brucei ?
-
 ?
2.7.7.52 UTP + RNAn the mitochondrial enzyme adds a single U to the 3'-end of single-stranded RNA Trypanosoma brucei diphosphate + RNAn+1
-
 ?
2.7.7.52 UTP + RNAn addition of non-coded poly(U) tail to gRNAs Trypanosoma brucei diphosphate + RNAn+1
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.7.52 3' terminal uridylyl transferase
-
 Trypanosoma brucei
2.7.7.52 RET i.e. RNA editing TUTase Trypanosoma brucei