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Literature summary extracted from

  • Vankatesan, S.; Moss, B.
    Donor and acceptor specificities of HeLa cell mRNA guanylyltransferase (1990), J. Biol. Chem., 255, 2835-2842.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.7.50 diphosphate 50% at 0.005 mM, complete at 0.05 mM Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.7.50 0.000019
-
 diphosphate-ended poly(A) pH 7.5, 37°C Homo sapiens
2.7.7.50 0.00014
-
 lambdac17RNA pH 7.5, 37°C Homo sapiens
2.7.7.50 0.000285
-
 pp(5')ApGp pH 7.5, 37°C Homo sapiens
2.7.7.50 0.0011
-
 GTP pH 7.5, 37°C Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.50 Homo sapiens
-
 HeLa cells
-

Reaction

EC Number Reaction Comment Organism Reaction ID
2.7.7.50 GTP + (5')ppPur-mRNA = diphosphate + G(5')pppPur-mRNA mechanism of capping Homo sapiens
a
2.7.7.50 GTP + (5')ppPur-mRNA = diphosphate + G(5')pppPur-mRNA mRNA containing a guanosine residue linked 5' through three phosphates to the 5' position of the terminal residue Homo sapiens
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.7.50 HeLa cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.50 dGTP + pp(5')RNA no activity Homo sapiens dG(5')ppp(5')RNA + diphosphate
-
 ?
2.7.7.50 GTP + diphosphate-ended poly(A)
-
 Homo sapiens ?
-
 ?
2.7.7.50 GTP + lambdac17RNA
-
 Homo sapiens ?
-
 ?
2.7.7.50 GTP + pp(5')ApGp
-
 Homo sapiens G(5')ppp(5')ApGp + diphosphate guanosine residue linked 5' through three phosphates to the 5' position of the terminal residue ir
2.7.7.50 GTP + pp(5')RNA the acceptor is diphosphate terminated poly(A) Homo sapiens G(5')ppp(5')RNA + diphosphate guanosine residue linked 5' through three phosphates to the 5' position of the terminal residue ?
2.7.7.50 GTP + ppp(5')ApGp
-
 Homo sapiens G(5')pppp(5')ApGp + diphosphate guanosine residue linked 5' through four phosphates to the 5' position of the terminal residue ?
2.7.7.50 ITP + pp(5')RNA
-
 Homo sapiens I(5')ppp(5')RNA + diphosphate inosine residue linked 5' through three phosphates to the 5' position of the terminal residue ir
2.7.7.50 additional information specificity overview Homo sapiens ?
-
 ?
2.7.7.50 additional information no activity with GDP Homo sapiens ?
-
 ?
2.7.7.50 additional information no activity with m7GTP Homo sapiens ?
-
 ?
2.7.7.50 additional information no activity with ATP, CTP, UTP Homo sapiens ?
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.7.50 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.7.50 7.5
-
 assay at Homo sapiens