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Literature summary extracted from

  • Chu, S.C.; Hsieh, Y.S.; Lin, J.Y.
    Inhibitory effects of flavonoids on Moloney murine leukemia virus reverse transcriptase activity (1992), J. Nat. Prod., 55, 179--183.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.7.49 (+)-catechin
-
 Moloney murine leukemia virus
2.7.7.49 (+)-taxifolin
-
 Moloney murine leukemia virus
2.7.7.49 (-)-epicatechin
-
 Moloney murine leukemia virus
2.7.7.49 fisetin
-
 Moloney murine leukemia virus
2.7.7.49 flavanonol low inhibition Moloney murine leukemia virus
2.7.7.49 flavone low inhibition Moloney murine leukemia virus
2.7.7.49 flavonol
-
 Moloney murine leukemia virus
2.7.7.49 kaempferol
-
 Moloney murine leukemia virus
2.7.7.49 additional information simultaneous presence of free hydroxyl groups at position 3 and 4' enhance the reverse transcriptase inhibitory activity. Replacement of the 3-hydroxyl group with a monosaccharide or of the 4'-hydroxyl group with a Me group reduces inhibitory activity. The double bond at position 2 and 3 of the flavonoid‘s pyrone ring is not essential for inhibiting reverse transcriptase activity Moloney murine leukemia virus
2.7.7.49 morin
-
 Moloney murine leukemia virus
2.7.7.49 myricetin
-
 Moloney murine leukemia virus
2.7.7.49 quercetin
-
 Moloney murine leukemia virus

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.49 Moloney murine leukemia virus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.49 deoxynucleoside triphosphate + DNAn
-
 Moloney murine leukemia virus diphosphate + DNAn+1
-
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