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Literature summary extracted from

  • Dowhan, W.
    CDP-diacylglycerol synthase of microorganisms (1997), Biochim. Biophys. Acta, 1348, 157-165.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.7.41 membrane integral protein of the inner membrane Escherichia coli 16020
-
2.7.7.41 mitochondrion enzyme is associated with both, the mitochondria and the endoplasmic reticulum Saccharomyces cerevisiae 5739
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.7.41 K+ stimulates Escherichia coli
2.7.7.41 K+ stimulates Saccharomyces cerevisiae
2.7.7.41 Mg2+ required Escherichia coli
2.7.7.41 Mg2+ the only divalent cation that supports activity Saccharomyces cerevisiae

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.7.41 114000
-
 radiation inactivation Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.7.41 CTP + phosphatidate Escherichia coli the enzyme is involved in the regulation of phospholipid metabolism diphosphate + CDPdiacylglycerol
-
 ?
2.7.7.41 CTP + phosphatidate Saccharomyces cerevisiae the enzyme is involved in the regulation of phospholipid metabolism diphosphate + CDPdiacylglycerol
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.41 Escherichia coli
-
-
-
2.7.7.41 Saccharomyces cerevisiae
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
2.7.7.41 CTP + phosphatidate = diphosphate + CDP-diacylglycerol sequential ordered reaction mechanism Escherichia coli
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.41 CTP + phosphatidate
-
 Saccharomyces cerevisiae diphosphate + CDPdiacylglycerol
-
 ?
2.7.7.41 CTP + phosphatidate strong preference for phosphatidic acid with 16-carbon and 18-carbon length fatty acids and at least one unsaturated fatty acid Escherichia coli diphosphate + CDPdiacylglycerol
-
 ?
2.7.7.41 CTP + phosphatidate the enzyme is involved in the regulation of phospholipid metabolism Escherichia coli diphosphate + CDPdiacylglycerol
-
 ?
2.7.7.41 CTP + phosphatidate the enzyme is involved in the regulation of phospholipid metabolism Saccharomyces cerevisiae diphosphate + CDPdiacylglycerol
-
 ?
2.7.7.41 dCTP + phosphatidate
-
 Saccharomyces cerevisiae diphosphate + dCDPdiacylglycerol
-
 ?
2.7.7.41 dCTP + phosphatidate reaction at the same rate as CTP Escherichia coli diphosphate + dCDPdiacylglycerol
-
 ?