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Literature summary extracted from

  • Martin, D.; Gannoun-Zaki, L.; Bonnefoy, S.; Eldin, P.; Wengelnik, K.; Vial, H.
    Characterization of Plasmodium falciparum CDP-diacylglycerol synthase, a proteolytically cleaved enzyme (2000), Mol. Biochem. Parasitol., 110, 93-105.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.7.41
-
 Plasmodium falciparum

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.7.41 CTP + phosphatidate Plasmodium falciparum the enzyme catalyzes the synthesis of CDPdiacylglycerol, an obligatory intermediate compound in the biosynthesis of the major anionic and zwitterionic phospholipids diphosphate + CDPdiacylglycerol
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.41 Plasmodium falciparum Q9NIH5
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.7.7.41 proteolytic modification N-terminal proteolytical processing form a protein of 51000 Da and a protein of 28000 Da from the 78000 Da protein Plasmodium falciparum

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.7.41 ring stage the enzyme is only weakly transcribed in ring stages, while major transcription occurs in the trophozoite and schizont stages Plasmodium falciparum
-
2.7.7.41 schizont the enzyme is only weakly transcribed in ring stages, while major transcription occurs in the trophozoite and schizont stages Plasmodium falciparum
-
2.7.7.41 trophozoite the enzyme is only weakly transcribed in ring stages, while major transcription occurs in the trophozoite and schizont stages Plasmodium falciparum
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.41 CTP + phosphatidate
-
 Plasmodium falciparum diphosphate + CDPdiacylglycerol
-
 ?
2.7.7.41 CTP + phosphatidate the enzyme catalyzes the synthesis of CDPdiacylglycerol, an obligatory intermediate compound in the biosynthesis of the major anionic and zwitterionic phospholipids Plasmodium falciparum diphosphate + CDPdiacylglycerol
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.7.41 ?
-
 Plasmodium falciparum

pI Value

EC Number Organism Comment pI Value Maximum pI Value
2.7.7.41 Plasmodium falciparum calculated from nucleotide sequence for full-length enzyme
-
 9.62