BRENDA - Enzyme Database

Characterization of Plasmodium falciparum CDP-diacylglycerol synthase, a proteolytically cleaved enzyme

Martin, D.; Gannoun-Zaki, L.; Bonnefoy, S.; Eldin, P.; Wengelnik, K.; Vial, H.; Mol. Biochem. Parasitol. 110, 93-105 (2000)

Data extracted from this reference:

Cloned(Commentary)
EC Number
Commentary
Organism
2.7.7.41
-
Plasmodium falciparum
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.7.7.41
CTP + phosphatidate
Plasmodium falciparum
the enzyme catalyzes the synthesis of CDPdiacylglycerol, an obligatory intermediate compound in the biosynthesis of the major anionic and zwitterionic phospholipids
diphosphate + CDPdiacylglycerol
-
-
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.7.7.41
Plasmodium falciparum
Q9NIH5
-
-
Posttranslational Modification
EC Number
Posttranslational Modification
Commentary
Organism
2.7.7.41
proteolytic modification
N-terminal proteolytical processing form a protein of 51000 Da and a protein of 28000 Da from the 78000 Da protein
Plasmodium falciparum
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
2.7.7.41
ring stage
the enzyme is only weakly transcribed in ring stages, while major transcription occurs in the trophozoite and schizont stages
Plasmodium falciparum
-
2.7.7.41
schizont
the enzyme is only weakly transcribed in ring stages, while major transcription occurs in the trophozoite and schizont stages
Plasmodium falciparum
-
2.7.7.41
trophozoite
the enzyme is only weakly transcribed in ring stages, while major transcription occurs in the trophozoite and schizont stages
Plasmodium falciparum
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.7.7.41
CTP + phosphatidate
-
643320
Plasmodium falciparum
diphosphate + CDPdiacylglycerol
-
-
-
?
2.7.7.41
CTP + phosphatidate
the enzyme catalyzes the synthesis of CDPdiacylglycerol, an obligatory intermediate compound in the biosynthesis of the major anionic and zwitterionic phospholipids
643320
Plasmodium falciparum
diphosphate + CDPdiacylglycerol
-
-
-
?
Subunits
EC Number
Subunits
Commentary
Organism
2.7.7.41
?
-
Plasmodium falciparum
pI Value
EC Number
Organism
Commentary
pI Value Maximum
pI Value
2.7.7.41
Plasmodium falciparum
calculated from nucleotide sequence for full-length enzyme
-
9.62
Cloned(Commentary) (protein specific)
EC Number
Commentary
Organism
2.7.7.41
-
Plasmodium falciparum
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.7.7.41
CTP + phosphatidate
Plasmodium falciparum
the enzyme catalyzes the synthesis of CDPdiacylglycerol, an obligatory intermediate compound in the biosynthesis of the major anionic and zwitterionic phospholipids
diphosphate + CDPdiacylglycerol
-
-
?
Posttranslational Modification (protein specific)
EC Number
Posttranslational Modification
Commentary
Organism
2.7.7.41
proteolytic modification
N-terminal proteolytical processing form a protein of 51000 Da and a protein of 28000 Da from the 78000 Da protein
Plasmodium falciparum
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
2.7.7.41
ring stage
the enzyme is only weakly transcribed in ring stages, while major transcription occurs in the trophozoite and schizont stages
Plasmodium falciparum
-
2.7.7.41
schizont
the enzyme is only weakly transcribed in ring stages, while major transcription occurs in the trophozoite and schizont stages
Plasmodium falciparum
-
2.7.7.41
trophozoite
the enzyme is only weakly transcribed in ring stages, while major transcription occurs in the trophozoite and schizont stages
Plasmodium falciparum
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.7.7.41
CTP + phosphatidate
-
643320
Plasmodium falciparum
diphosphate + CDPdiacylglycerol
-
-
-
?
2.7.7.41
CTP + phosphatidate
the enzyme catalyzes the synthesis of CDPdiacylglycerol, an obligatory intermediate compound in the biosynthesis of the major anionic and zwitterionic phospholipids
643320
Plasmodium falciparum
diphosphate + CDPdiacylglycerol
-
-
-
?
Subunits (protein specific)
EC Number
Subunits
Commentary
Organism
2.7.7.41
?
-
Plasmodium falciparum
pI Value (protein specific)
EC Number
Organism
Commentary
pI Value Maximum
pI Value
2.7.7.41
Plasmodium falciparum
calculated from nucleotide sequence for full-length enzyme
-
9.62