BRENDA - Enzyme Database

CDP-diacylglycerol synthase from mammalian tissues

Heacock, A.M.; Agranoff, B.W.; Biochim. Biophys. Acta 1348, 166-172 (1997)

Data extracted from this reference:

Cloned(Commentary)
EC Number
Commentary
Organism
2.7.7.41
-
Homo sapiens
KM Value [mM]
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
2.7.7.41
1
-
CTP
-
Cavia porcellus
2.7.7.41
2.5
-
phosphatidate
-
Cavia porcellus
Localization
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
2.7.7.41
microsome
predominantly located in
Rattus norvegicus
-
-
2.7.7.41
mitochondrion
5-10% of the cellular activity
Rattus norvegicus
5739
-
Metals/Ions
EC Number
Metals/Ions
Commentary
Organism
Structure
2.7.7.41
Mg2+
-
Escherichia coli
2.7.7.41
Mg2+
50-60 mM required for optimal activity
Rattus norvegicus
2.7.7.41
Mg2+
-
Sus scrofa
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.7.7.41
CTP + phosphatidate
Cavia porcellus
mammalian enzymes show similar efficacy for CTP and dCTP, however CTP is the preferred substrate in vivo, since dCDP-diacylglycerol is not detectable in mammalian tissues. In Escherichia coli equivalent amounts of CDP-diacylglycerol and dCDP-diacylglycerol are detected. Arabinofuranosylcytosine is also found to be incorporated into lipid in mammalian cells, suggesting that it is a substrate for the enzyme
diphosphate + CDPdiacylglycerol
-
-
-
2.7.7.41
CTP + phosphatidate
Escherichia coli
mammalian enzymes show similar efficacy for CTP and dCTP, however CTP is the preferred substrate in vivo, since dCDP-diacylglycerol is not detectable in mammalian tissues. In Escherichia coli equivalent amounts of CDP-diacylglycerol and dCDP-diacylglycerol are detected. Arabinofuranosylcytosine is also found to be incorporated into lipid in mammalian cells, suggesting that it is a substrate for the enzyme
diphosphate + CDPdiacylglycerol
-
-
?
2.7.7.41
CTP + phosphatidate
Homo sapiens
mammalian enzymes show similar efficacy for CTP and dCTP, however CTP is the preferred substrate in vivo, since dCDP-diacylglycerol is not detectable in mammalian tissues. In Escherichia coli equivalent amounts of CDP-diacylglycerol and dCDP-diacylglycerol are detected. Arabinofuranosylcytosine is also found to be incorporated into lipid in mammalian cells, suggesting that it is a substrate for the enzyme
diphosphate + CDPdiacylglycerol
-
-
?
2.7.7.41
CTP + phosphatidate
Rattus norvegicus
mammalian enzymes show similar efficacy for CTP and dCTP, however CTP is the preferred substrate in vivo, since dCDP-diacylglycerol is not detectable in mammalian tissues. In Escherichia coli equivalent amounts of CDP-diacylglycerol and dCDP-diacylglycerol are detected. Arabinofuranosylcytosine is also found to be incorporated into lipid in mammalian cells, suggesting that it is a substrate for the enzyme
diphosphate + CDPdiacylglycerol
-
-
?
2.7.7.41
CTP + phosphatidate
Sus scrofa
mammalian enzymes show similar efficacy for CTP and dCTP, however CTP is the preferred substrate in vivo, since dCDP-diacylglycerol is not detectable in mammalian tissues. In Escherichia coli equivalent amounts of CDP-diacylglycerol and dCDP-diacylglycerol are detected. Arabinofuranosylcytosine is also found to be incorporated into lipid in mammalian cells, suggesting that it is a substrate for the enzyme
diphosphate + CDPdiacylglycerol
-
-
-
2.7.7.41
CTP + phosphatidate
Rattus norvegicus
enzyme plays a central role in phospholipid biosynthesis
diphosphate + CDPdiacylglycerol
-
-
?
2.7.7.41
CTP + phosphatidate
Drosophila sp. (in: Insecta)
the enzyme plays a regulatory role in phototransduction by ensuring an adequate supply of phosphatidylinositol-4,5-diphosphate
diphosphate + CDPdiacylglycerol
-
-
?
2.7.7.41
dCTP + phosphatidate
Cavia porcellus
mammalian enzymes show similar efficacy for CTP and dCTP, however CTP is the preferred substrate in vivo, since dCDP-diacylglycerol is not detectable in mammalian tissues. In Escherichia coli equivalent amounts of CDP-diacylglycerol and dCDP-diacylglycerol are detected. Arabinofuranosylcytosine is also found to be incorporated into lipid in mammalian cells, suggesting that it is a substrate for the enzyme
diphosphate + dCDPdiacylglycerol
-
-
?
2.7.7.41
dCTP + phosphatidate
Escherichia coli
mammalian enzymes show similar efficacy for CTP and dCTP, however CTP is the preferred substrate in vivo, since dCDP-diacylglycerol is not detectable in mammalian tissues. In Escherichia coli equivalent amounts of CDP-diacylglycerol and dCDP-diacylglycerol are detected. Arabinofuranosylcytosine is also found to be incorporated into lipid in mammalian cells, suggesting that it is a substrate for the enzyme
diphosphate + dCDPdiacylglycerol
-
-
?
2.7.7.41
dCTP + phosphatidate
Homo sapiens
mammalian enzymes show similar efficacy for CTP and dCTP, however CTP is the preferred substrate in vivo, since dCDP-diacylglycerol is not detectable in mammalian tissues. In Escherichia coli equivalent amounts of CDP-diacylglycerol and dCDP-diacylglycerol are detected. Arabinofuranosylcytosine is also found to be incorporated into lipid in mammalian cells, suggesting that it is a substrate for the enzyme
diphosphate + dCDPdiacylglycerol
-
-
?
2.7.7.41
dCTP + phosphatidate
Rattus norvegicus
mammalian enzymes show similar efficacy for CTP and dCTP, however CTP is the preferred substrate in vivo, since dCDP-diacylglycerol is not detectable in mammalian tissues. In Escherichia coli equivalent amounts of CDP-diacylglycerol and dCDP-diacylglycerol are detected. Arabinofuranosylcytosine is also found to be incorporated into lipid in mammalian cells, suggesting that it is a substrate for the enzyme
diphosphate + dCDPdiacylglycerol
-
-
?
2.7.7.41
dCTP + phosphatidate
Sus scrofa
mammalian enzymes show similar efficacy for CTP and dCTP, however CTP is the preferred substrate in vivo, since dCDP-diacylglycerol is not detectable in mammalian tissues. In Escherichia coli equivalent amounts of CDP-diacylglycerol and dCDP-diacylglycerol are detected. Arabinofuranosylcytosine is also found to be incorporated into lipid in mammalian cells, suggesting that it is a substrate for the enzyme
diphosphate + dCDPdiacylglycerol
-
-
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.7.7.41
Cavia porcellus
-
-
-
2.7.7.41
Drosophila sp. (in: Insecta)
-
-
-
2.7.7.41
Escherichia coli
-
-
-
2.7.7.41
Homo sapiens
-
-
-
2.7.7.41
Rattus norvegicus
-
-
-
2.7.7.41
Sus scrofa
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
2.7.7.41
brain
-
Rattus norvegicus
-
2.7.7.41
eye
-
Drosophila sp. (in: Insecta)
-
2.7.7.41
liver
-
Cavia porcellus
-
2.7.7.41
liver
-
Rattus norvegicus
-
2.7.7.41
neuronal cell line
-
Homo sapiens
-
2.7.7.41
skeletal muscle
low activity
Rattus norvegicus
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.7.7.41
CTP + phosphatidate
-
643319
Cavia porcellus
diphosphate + CDPdiacylglycerol
-
-
-
?
2.7.7.41
CTP + phosphatidate
-
643319
Drosophila sp. (in: Insecta)
diphosphate + CDPdiacylglycerol
-
-
-
?
2.7.7.41
CTP + phosphatidate
-
643319
Escherichia coli
diphosphate + CDPdiacylglycerol
-
-
-
?
2.7.7.41
CTP + phosphatidate
-
643319
Homo sapiens
diphosphate + CDPdiacylglycerol
-
-
-
?
2.7.7.41
CTP + phosphatidate
-
643319
Rattus norvegicus
diphosphate + CDPdiacylglycerol
-
-
-
?
2.7.7.41
CTP + phosphatidate
-
643319
Sus scrofa
diphosphate + CDPdiacylglycerol
-
-
-
?
2.7.7.41
CTP + phosphatidate
mammalian enzymes show similar efficacy for CTP and dCTP, however CTP is the preferred substrate in vivo, since dCDP-diacylglycerol is not detectable in mammalian tissues. In Escherichia coli equivalent amounts of CDP-diacylglycerol and dCDP-diacylglycerol are detected. Arabinofuranosylcytosine is also found to be incorporated into lipid in mammalian cells, suggesting that it is a substrate for the enzyme
643319
Cavia porcellus
diphosphate + CDPdiacylglycerol
-
-
-
-
2.7.7.41
CTP + phosphatidate
mammalian enzymes show similar efficacy for CTP and dCTP, however CTP is the preferred substrate in vivo, since dCDP-diacylglycerol is not detectable in mammalian tissues. In Escherichia coli equivalent amounts of CDP-diacylglycerol and dCDP-diacylglycerol are detected. Arabinofuranosylcytosine is also found to be incorporated into lipid in mammalian cells, suggesting that it is a substrate for the enzyme
643319
Escherichia coli
diphosphate + CDPdiacylglycerol
-
-
-
?
2.7.7.41
CTP + phosphatidate
mammalian enzymes show similar efficacy for CTP and dCTP, however CTP is the preferred substrate in vivo, since dCDP-diacylglycerol is not detectable in mammalian tissues. In Escherichia coli equivalent amounts of CDP-diacylglycerol and dCDP-diacylglycerol are detected. Arabinofuranosylcytosine is also found to be incorporated into lipid in mammalian cells, suggesting that it is a substrate for the enzyme
643319
Homo sapiens
diphosphate + CDPdiacylglycerol
-
-
-
?
2.7.7.41
CTP + phosphatidate
mammalian enzymes show similar efficacy for CTP and dCTP, however CTP is the preferred substrate in vivo, since dCDP-diacylglycerol is not detectable in mammalian tissues. In Escherichia coli equivalent amounts of CDP-diacylglycerol and dCDP-diacylglycerol are detected. Arabinofuranosylcytosine is also found to be incorporated into lipid in mammalian cells, suggesting that it is a substrate for the enzyme
643319
Rattus norvegicus
diphosphate + CDPdiacylglycerol
-
-
-
?
2.7.7.41
CTP + phosphatidate
mammalian enzymes show similar efficacy for CTP and dCTP, however CTP is the preferred substrate in vivo, since dCDP-diacylglycerol is not detectable in mammalian tissues. In Escherichia coli equivalent amounts of CDP-diacylglycerol and dCDP-diacylglycerol are detected. Arabinofuranosylcytosine is also found to be incorporated into lipid in mammalian cells, suggesting that it is a substrate for the enzyme
643319
Sus scrofa
diphosphate + CDPdiacylglycerol
-
-
-
-
2.7.7.41
CTP + phosphatidate
enzyme plays a central role in phospholipid biosynthesis
643319
Rattus norvegicus
diphosphate + CDPdiacylglycerol
-
-
-
?
2.7.7.41
CTP + phosphatidate
the enzyme plays a regulatory role in phototransduction by ensuring an adequate supply of phosphatidylinositol-4,5-diphosphate
643319
Drosophila sp. (in: Insecta)
diphosphate + CDPdiacylglycerol
-
-
-
?
2.7.7.41
dCTP + phosphatidate
-
643319
Cavia porcellus
diphosphate + dCDPdiacylglycerol
-
-
-
-
2.7.7.41
dCTP + phosphatidate
-
643319
Homo sapiens
diphosphate + dCDPdiacylglycerol
-
-
-
-
2.7.7.41
dCTP + phosphatidate
-
643319
Rattus norvegicus
diphosphate + dCDPdiacylglycerol
-
-
-
?
2.7.7.41
dCTP + phosphatidate
-
643319
Sus scrofa
diphosphate + dCDPdiacylglycerol
-
-
-
-
2.7.7.41
dCTP + phosphatidate
reaction at the same rate as CTP
643319
Escherichia coli
diphosphate + dCDPdiacylglycerol
-
-
-
?
2.7.7.41
dCTP + phosphatidate
mammalian enzymes show similar efficacy for CTP and dCTP, however CTP is the preferred substrate in vivo, since dCDP-diacylglycerol is not detectable in mammalian tissues. In Escherichia coli equivalent amounts of CDP-diacylglycerol and dCDP-diacylglycerol are detected. Arabinofuranosylcytosine is also found to be incorporated into lipid in mammalian cells, suggesting that it is a substrate for the enzyme
643319
Cavia porcellus
diphosphate + dCDPdiacylglycerol
-
-
-
?
2.7.7.41
dCTP + phosphatidate
mammalian enzymes show similar efficacy for CTP and dCTP, however CTP is the preferred substrate in vivo, since dCDP-diacylglycerol is not detectable in mammalian tissues. In Escherichia coli equivalent amounts of CDP-diacylglycerol and dCDP-diacylglycerol are detected. Arabinofuranosylcytosine is also found to be incorporated into lipid in mammalian cells, suggesting that it is a substrate for the enzyme
643319
Escherichia coli
diphosphate + dCDPdiacylglycerol
-
-
-
?
2.7.7.41
dCTP + phosphatidate
mammalian enzymes show similar efficacy for CTP and dCTP, however CTP is the preferred substrate in vivo, since dCDP-diacylglycerol is not detectable in mammalian tissues. In Escherichia coli equivalent amounts of CDP-diacylglycerol and dCDP-diacylglycerol are detected. Arabinofuranosylcytosine is also found to be incorporated into lipid in mammalian cells, suggesting that it is a substrate for the enzyme
643319
Homo sapiens
diphosphate + dCDPdiacylglycerol
-
-
-
?
2.7.7.41
dCTP + phosphatidate
mammalian enzymes show similar efficacy for CTP and dCTP, however CTP is the preferred substrate in vivo, since dCDP-diacylglycerol is not detectable in mammalian tissues. In Escherichia coli equivalent amounts of CDP-diacylglycerol and dCDP-diacylglycerol are detected. Arabinofuranosylcytosine is also found to be incorporated into lipid in mammalian cells, suggesting that it is a substrate for the enzyme
643319
Rattus norvegicus
diphosphate + dCDPdiacylglycerol
-
-
-
?
2.7.7.41
dCTP + phosphatidate
mammalian enzymes show similar efficacy for CTP and dCTP, however CTP is the preferred substrate in vivo, since dCDP-diacylglycerol is not detectable in mammalian tissues. In Escherichia coli equivalent amounts of CDP-diacylglycerol and dCDP-diacylglycerol are detected. Arabinofuranosylcytosine is also found to be incorporated into lipid in mammalian cells, suggesting that it is a substrate for the enzyme
643319
Sus scrofa
diphosphate + dCDPdiacylglycerol
-
-
-
?
pH Optimum
EC Number
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
2.7.7.41
6.8
-
-
Rattus norvegicus
Cloned(Commentary) (protein specific)
EC Number
Commentary
Organism
2.7.7.41
-
Homo sapiens
KM Value [mM] (protein specific)
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
2.7.7.41
1
-
CTP
-
Cavia porcellus
2.7.7.41
2.5
-
phosphatidate
-
Cavia porcellus
Localization (protein specific)
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
2.7.7.41
microsome
predominantly located in
Rattus norvegicus
-
-
2.7.7.41
mitochondrion
5-10% of the cellular activity
Rattus norvegicus
5739
-
Metals/Ions (protein specific)
EC Number
Metals/Ions
Commentary
Organism
Structure
2.7.7.41
Mg2+
-
Escherichia coli
2.7.7.41
Mg2+
50-60 mM required for optimal activity
Rattus norvegicus
2.7.7.41
Mg2+
-
Sus scrofa
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.7.7.41
CTP + phosphatidate
Cavia porcellus
mammalian enzymes show similar efficacy for CTP and dCTP, however CTP is the preferred substrate in vivo, since dCDP-diacylglycerol is not detectable in mammalian tissues. In Escherichia coli equivalent amounts of CDP-diacylglycerol and dCDP-diacylglycerol are detected. Arabinofuranosylcytosine is also found to be incorporated into lipid in mammalian cells, suggesting that it is a substrate for the enzyme
diphosphate + CDPdiacylglycerol
-
-
-
2.7.7.41
CTP + phosphatidate
Escherichia coli
mammalian enzymes show similar efficacy for CTP and dCTP, however CTP is the preferred substrate in vivo, since dCDP-diacylglycerol is not detectable in mammalian tissues. In Escherichia coli equivalent amounts of CDP-diacylglycerol and dCDP-diacylglycerol are detected. Arabinofuranosylcytosine is also found to be incorporated into lipid in mammalian cells, suggesting that it is a substrate for the enzyme
diphosphate + CDPdiacylglycerol
-
-
?
2.7.7.41
CTP + phosphatidate
Homo sapiens
mammalian enzymes show similar efficacy for CTP and dCTP, however CTP is the preferred substrate in vivo, since dCDP-diacylglycerol is not detectable in mammalian tissues. In Escherichia coli equivalent amounts of CDP-diacylglycerol and dCDP-diacylglycerol are detected. Arabinofuranosylcytosine is also found to be incorporated into lipid in mammalian cells, suggesting that it is a substrate for the enzyme
diphosphate + CDPdiacylglycerol
-
-
?
2.7.7.41
CTP + phosphatidate
Rattus norvegicus
mammalian enzymes show similar efficacy for CTP and dCTP, however CTP is the preferred substrate in vivo, since dCDP-diacylglycerol is not detectable in mammalian tissues. In Escherichia coli equivalent amounts of CDP-diacylglycerol and dCDP-diacylglycerol are detected. Arabinofuranosylcytosine is also found to be incorporated into lipid in mammalian cells, suggesting that it is a substrate for the enzyme
diphosphate + CDPdiacylglycerol
-
-
?
2.7.7.41
CTP + phosphatidate
Sus scrofa
mammalian enzymes show similar efficacy for CTP and dCTP, however CTP is the preferred substrate in vivo, since dCDP-diacylglycerol is not detectable in mammalian tissues. In Escherichia coli equivalent amounts of CDP-diacylglycerol and dCDP-diacylglycerol are detected. Arabinofuranosylcytosine is also found to be incorporated into lipid in mammalian cells, suggesting that it is a substrate for the enzyme
diphosphate + CDPdiacylglycerol
-
-
-
2.7.7.41
CTP + phosphatidate
Rattus norvegicus
enzyme plays a central role in phospholipid biosynthesis
diphosphate + CDPdiacylglycerol
-
-
?
2.7.7.41
CTP + phosphatidate
Drosophila sp. (in: Insecta)
the enzyme plays a regulatory role in phototransduction by ensuring an adequate supply of phosphatidylinositol-4,5-diphosphate
diphosphate + CDPdiacylglycerol
-
-
?
2.7.7.41
dCTP + phosphatidate
Cavia porcellus
mammalian enzymes show similar efficacy for CTP and dCTP, however CTP is the preferred substrate in vivo, since dCDP-diacylglycerol is not detectable in mammalian tissues. In Escherichia coli equivalent amounts of CDP-diacylglycerol and dCDP-diacylglycerol are detected. Arabinofuranosylcytosine is also found to be incorporated into lipid in mammalian cells, suggesting that it is a substrate for the enzyme
diphosphate + dCDPdiacylglycerol
-
-
?
2.7.7.41
dCTP + phosphatidate
Escherichia coli
mammalian enzymes show similar efficacy for CTP and dCTP, however CTP is the preferred substrate in vivo, since dCDP-diacylglycerol is not detectable in mammalian tissues. In Escherichia coli equivalent amounts of CDP-diacylglycerol and dCDP-diacylglycerol are detected. Arabinofuranosylcytosine is also found to be incorporated into lipid in mammalian cells, suggesting that it is a substrate for the enzyme
diphosphate + dCDPdiacylglycerol
-
-
?
2.7.7.41
dCTP + phosphatidate
Homo sapiens
mammalian enzymes show similar efficacy for CTP and dCTP, however CTP is the preferred substrate in vivo, since dCDP-diacylglycerol is not detectable in mammalian tissues. In Escherichia coli equivalent amounts of CDP-diacylglycerol and dCDP-diacylglycerol are detected. Arabinofuranosylcytosine is also found to be incorporated into lipid in mammalian cells, suggesting that it is a substrate for the enzyme
diphosphate + dCDPdiacylglycerol
-
-
?
2.7.7.41
dCTP + phosphatidate
Rattus norvegicus
mammalian enzymes show similar efficacy for CTP and dCTP, however CTP is the preferred substrate in vivo, since dCDP-diacylglycerol is not detectable in mammalian tissues. In Escherichia coli equivalent amounts of CDP-diacylglycerol and dCDP-diacylglycerol are detected. Arabinofuranosylcytosine is also found to be incorporated into lipid in mammalian cells, suggesting that it is a substrate for the enzyme
diphosphate + dCDPdiacylglycerol
-
-
?
2.7.7.41
dCTP + phosphatidate
Sus scrofa
mammalian enzymes show similar efficacy for CTP and dCTP, however CTP is the preferred substrate in vivo, since dCDP-diacylglycerol is not detectable in mammalian tissues. In Escherichia coli equivalent amounts of CDP-diacylglycerol and dCDP-diacylglycerol are detected. Arabinofuranosylcytosine is also found to be incorporated into lipid in mammalian cells, suggesting that it is a substrate for the enzyme
diphosphate + dCDPdiacylglycerol
-
-
?
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
2.7.7.41
brain
-
Rattus norvegicus
-
2.7.7.41
eye
-
Drosophila sp. (in: Insecta)
-
2.7.7.41
liver
-
Cavia porcellus
-
2.7.7.41
liver
-
Rattus norvegicus
-
2.7.7.41
neuronal cell line
-
Homo sapiens
-
2.7.7.41
skeletal muscle
low activity
Rattus norvegicus
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.7.7.41
CTP + phosphatidate
-
643319
Cavia porcellus
diphosphate + CDPdiacylglycerol
-
-
-
?
2.7.7.41
CTP + phosphatidate
-
643319
Drosophila sp. (in: Insecta)
diphosphate + CDPdiacylglycerol
-
-
-
?
2.7.7.41
CTP + phosphatidate
-
643319
Escherichia coli
diphosphate + CDPdiacylglycerol
-
-
-
?
2.7.7.41
CTP + phosphatidate
-
643319
Homo sapiens
diphosphate + CDPdiacylglycerol
-
-
-
?
2.7.7.41
CTP + phosphatidate
-
643319
Rattus norvegicus
diphosphate + CDPdiacylglycerol
-
-
-
?
2.7.7.41
CTP + phosphatidate
-
643319
Sus scrofa
diphosphate + CDPdiacylglycerol
-
-
-
?
2.7.7.41
CTP + phosphatidate
mammalian enzymes show similar efficacy for CTP and dCTP, however CTP is the preferred substrate in vivo, since dCDP-diacylglycerol is not detectable in mammalian tissues. In Escherichia coli equivalent amounts of CDP-diacylglycerol and dCDP-diacylglycerol are detected. Arabinofuranosylcytosine is also found to be incorporated into lipid in mammalian cells, suggesting that it is a substrate for the enzyme
643319
Cavia porcellus
diphosphate + CDPdiacylglycerol
-
-
-
-
2.7.7.41
CTP + phosphatidate
mammalian enzymes show similar efficacy for CTP and dCTP, however CTP is the preferred substrate in vivo, since dCDP-diacylglycerol is not detectable in mammalian tissues. In Escherichia coli equivalent amounts of CDP-diacylglycerol and dCDP-diacylglycerol are detected. Arabinofuranosylcytosine is also found to be incorporated into lipid in mammalian cells, suggesting that it is a substrate for the enzyme
643319
Escherichia coli
diphosphate + CDPdiacylglycerol
-
-
-
?
2.7.7.41
CTP + phosphatidate
mammalian enzymes show similar efficacy for CTP and dCTP, however CTP is the preferred substrate in vivo, since dCDP-diacylglycerol is not detectable in mammalian tissues. In Escherichia coli equivalent amounts of CDP-diacylglycerol and dCDP-diacylglycerol are detected. Arabinofuranosylcytosine is also found to be incorporated into lipid in mammalian cells, suggesting that it is a substrate for the enzyme
643319
Homo sapiens
diphosphate + CDPdiacylglycerol
-
-
-
?
2.7.7.41
CTP + phosphatidate
mammalian enzymes show similar efficacy for CTP and dCTP, however CTP is the preferred substrate in vivo, since dCDP-diacylglycerol is not detectable in mammalian tissues. In Escherichia coli equivalent amounts of CDP-diacylglycerol and dCDP-diacylglycerol are detected. Arabinofuranosylcytosine is also found to be incorporated into lipid in mammalian cells, suggesting that it is a substrate for the enzyme
643319
Rattus norvegicus
diphosphate + CDPdiacylglycerol
-
-
-
?
2.7.7.41
CTP + phosphatidate
mammalian enzymes show similar efficacy for CTP and dCTP, however CTP is the preferred substrate in vivo, since dCDP-diacylglycerol is not detectable in mammalian tissues. In Escherichia coli equivalent amounts of CDP-diacylglycerol and dCDP-diacylglycerol are detected. Arabinofuranosylcytosine is also found to be incorporated into lipid in mammalian cells, suggesting that it is a substrate for the enzyme
643319
Sus scrofa
diphosphate + CDPdiacylglycerol
-
-
-
-
2.7.7.41
CTP + phosphatidate
enzyme plays a central role in phospholipid biosynthesis
643319
Rattus norvegicus
diphosphate + CDPdiacylglycerol
-
-
-
?
2.7.7.41
CTP + phosphatidate
the enzyme plays a regulatory role in phototransduction by ensuring an adequate supply of phosphatidylinositol-4,5-diphosphate
643319
Drosophila sp. (in: Insecta)
diphosphate + CDPdiacylglycerol
-
-
-
?
2.7.7.41
dCTP + phosphatidate
-
643319
Cavia porcellus
diphosphate + dCDPdiacylglycerol
-
-
-
-
2.7.7.41
dCTP + phosphatidate
-
643319
Homo sapiens
diphosphate + dCDPdiacylglycerol
-
-
-
-
2.7.7.41
dCTP + phosphatidate
-
643319
Rattus norvegicus
diphosphate + dCDPdiacylglycerol
-
-
-
?
2.7.7.41
dCTP + phosphatidate
-
643319
Sus scrofa
diphosphate + dCDPdiacylglycerol
-
-
-
-
2.7.7.41
dCTP + phosphatidate
reaction at the same rate as CTP
643319
Escherichia coli
diphosphate + dCDPdiacylglycerol
-
-
-
?
2.7.7.41
dCTP + phosphatidate
mammalian enzymes show similar efficacy for CTP and dCTP, however CTP is the preferred substrate in vivo, since dCDP-diacylglycerol is not detectable in mammalian tissues. In Escherichia coli equivalent amounts of CDP-diacylglycerol and dCDP-diacylglycerol are detected. Arabinofuranosylcytosine is also found to be incorporated into lipid in mammalian cells, suggesting that it is a substrate for the enzyme
643319
Cavia porcellus
diphosphate + dCDPdiacylglycerol
-
-
-
?
2.7.7.41
dCTP + phosphatidate
mammalian enzymes show similar efficacy for CTP and dCTP, however CTP is the preferred substrate in vivo, since dCDP-diacylglycerol is not detectable in mammalian tissues. In Escherichia coli equivalent amounts of CDP-diacylglycerol and dCDP-diacylglycerol are detected. Arabinofuranosylcytosine is also found to be incorporated into lipid in mammalian cells, suggesting that it is a substrate for the enzyme
643319
Escherichia coli
diphosphate + dCDPdiacylglycerol
-
-
-
?
2.7.7.41
dCTP + phosphatidate
mammalian enzymes show similar efficacy for CTP and dCTP, however CTP is the preferred substrate in vivo, since dCDP-diacylglycerol is not detectable in mammalian tissues. In Escherichia coli equivalent amounts of CDP-diacylglycerol and dCDP-diacylglycerol are detected. Arabinofuranosylcytosine is also found to be incorporated into lipid in mammalian cells, suggesting that it is a substrate for the enzyme
643319
Homo sapiens
diphosphate + dCDPdiacylglycerol
-
-
-
?
2.7.7.41
dCTP + phosphatidate
mammalian enzymes show similar efficacy for CTP and dCTP, however CTP is the preferred substrate in vivo, since dCDP-diacylglycerol is not detectable in mammalian tissues. In Escherichia coli equivalent amounts of CDP-diacylglycerol and dCDP-diacylglycerol are detected. Arabinofuranosylcytosine is also found to be incorporated into lipid in mammalian cells, suggesting that it is a substrate for the enzyme
643319
Rattus norvegicus
diphosphate + dCDPdiacylglycerol
-
-
-
?
2.7.7.41
dCTP + phosphatidate
mammalian enzymes show similar efficacy for CTP and dCTP, however CTP is the preferred substrate in vivo, since dCDP-diacylglycerol is not detectable in mammalian tissues. In Escherichia coli equivalent amounts of CDP-diacylglycerol and dCDP-diacylglycerol are detected. Arabinofuranosylcytosine is also found to be incorporated into lipid in mammalian cells, suggesting that it is a substrate for the enzyme
643319
Sus scrofa
diphosphate + dCDPdiacylglycerol
-
-
-
?
pH Optimum (protein specific)
EC Number
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
2.7.7.41
6.8
-
-
Rattus norvegicus