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Literature summary extracted from

  • Hoagland, M.B.; Novelli, G.D.
    Biosynthesis of coenzyme A from phosphopantetheine from pantothenate (1954), J. Biol. Chem., 207, 767-773.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.1.24 cysteine activation Rattus norvegicus
2.7.1.24 cysteine activation Sus scrofa
2.7.1.24 cysteine activation Columba sp.
2.7.1.24 cysteine in vitro Rattus norvegicus
2.7.1.24 cysteine in vitro Sus scrofa
2.7.1.24 cysteine in vitro Columba sp.
2.7.7.3 cysteine
-
 Rattus norvegicus
2.7.7.3 cysteine activation, in vitro Sus scrofa

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.1.24 cytosol
-
 Rattus norvegicus 5829
-
2.7.1.24 cytosol
-
 Sus scrofa 5829
-
2.7.1.24 cytosol
-
 Columba sp. 5829
-
2.7.1.24 mitochondrion
-
 Rattus norvegicus 5739
-
2.7.1.24 mitochondrion
-
 Sus scrofa 5739
-
2.7.1.24 mitochondrion
-
 Columba sp. 5739
-
2.7.7.3 cytosol
-
 Rattus norvegicus 5829
-
2.7.7.3 cytosol
-
 Sus scrofa 5829
-
2.7.7.3 cytosol
-
 Columba sp. 5829
-
2.7.7.3 mitochondrion
-
 Rattus norvegicus 5739
-
2.7.7.3 mitochondrion
-
 Sus scrofa 5739
-
2.7.7.3 mitochondrion
-
 Columba sp. 5739
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.1.24 H2S activation, in vitro Rattus norvegicus
2.7.1.24 H2S activation, in vitro Sus scrofa
2.7.1.24 H2S activation, in vitro Columba sp.
2.7.1.24 Mg2+ requirement Rattus norvegicus
2.7.1.24 Mg2+ requirement Sus scrofa
2.7.1.24 Mg2+ requirement Columba sp.
2.7.1.24 Mg2+ 2 mM Rattus norvegicus
2.7.1.24 Mg2+ 2 mM Sus scrofa
2.7.1.24 Mg2+ 2 mM Columba sp.
2.7.7.3 Mg2+
-
 Rattus norvegicus
2.7.7.3 Mg2+ requirement, 2 mM Sus scrofa

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.7.3 ATP + pantetheine 4'-phosphate Rattus norvegicus
-
 diphosphate + 3'-dephospho-CoA
-
 r
2.7.7.3 ATP + pantetheine 4'-phosphate Sus scrofa
-
 diphosphate + 3'-dephospho-CoA
-
 r
2.7.7.3 ATP + pantetheine 4'-phosphate Columba sp.
-
 diphosphate + 3'-dephospho-CoA
-
 r
4.1.1.30 N-[(R)-pantothenoyl]-L-cysteine Rattus norvegicus
-
 pantetheine + CO2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.24 Columba sp.
-
-
-
2.7.1.24 Rattus norvegicus
-
-
-
2.7.1.24 Sus scrofa
-
-
-
2.7.7.3 Columba sp.
-
-
-
2.7.7.3 Rattus norvegicus
-
-
-
2.7.7.3 Sus scrofa
-
-
-
4.1.1.30 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.1.24 partial Sus scrofa
2.7.7.3 partial Sus scrofa

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.24 liver
-
 Rattus norvegicus
-
2.7.1.24 liver
-
 Sus scrofa
-
2.7.1.24 liver
-
 Columba sp.
-
2.7.7.3 liver
-
 Rattus norvegicus
-
2.7.7.3 liver
-
 Sus scrofa
-
2.7.7.3 liver
-
 Columba sp.
-
4.1.1.30 liver
-
 Rattus norvegicus
-

Storage Stability

EC Number Storage Stability Organism
2.7.1.24 frozen, partially purified preparation, quite stable Sus scrofa

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.24 ATP + dephospho-CoA
-
 Rattus norvegicus ADP + CoA
-
 ?
2.7.1.24 ATP + dephospho-CoA
-
 Sus scrofa ADP + CoA
-
 ?
2.7.1.24 ATP + dephospho-CoA
-
 Columba sp. ADP + CoA
-
 ?
2.7.7.3 ATP + pantetheine 4'-phosphate
-
 Rattus norvegicus diphosphate + 3'-dephospho-CoA
-
 r
2.7.7.3 ATP + pantetheine 4'-phosphate
-
 Sus scrofa diphosphate + 3'-dephospho-CoA
-
 r
2.7.7.3 ATP + pantetheine 4'-phosphate
-
 Columba sp. diphosphate + 3'-dephospho-CoA
-
 r
4.1.1.30 N-[(R)-pantothenoyl]-L-cysteine
-
 Rattus norvegicus pantetheine + CO2
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.1.24 37
-
 assay at Rattus norvegicus
2.7.1.24 37
-
 assay at Sus scrofa
2.7.1.24 37
-
 assay at Columba sp.
2.7.7.3 37
-
 assay at Rattus norvegicus
2.7.7.3 37
-
 assay at Sus scrofa
2.7.7.3 37
-
 assay at Columba sp.

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.1.24 9
-
-
 Rattus norvegicus
2.7.1.24 9
-
-
 Sus scrofa
2.7.1.24 9
-
-
 Columba sp.
2.7.7.3 7.5
-
-
 Sus scrofa