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Literature summary extracted from

  • Yamamoto, K.; Moriguchi, M.; Kawai, H.; Tochikura, T.
    Inhibition of UDP-N-acetylglucosamine pyrophosphorylase by uridine (1980), Biochim. Biophys. Acta, 614, 367-372.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.7.23 1-[(2S,3S,4R,5S)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]dihydropyrimidine-2,4(1H,3H)-dione
-
 Neurospora crassa
2.7.7.23 1-[(2S,3S,4R,5S)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]dihydropyrimidine-2,4(1H,3H)-dione
-
 Saccharomyces cerevisiae
2.7.7.23 5-Hydroxyuridine
-
 Neurospora crassa
2.7.7.23 5-Hydroxyuridine
-
 Saccharomyces cerevisiae
2.7.7.23 pseudouridine
-
 Neurospora crassa
2.7.7.23 pseudouridine
-
 Saccharomyces cerevisiae
2.7.7.23 uridine
-
 Neurospora crassa
2.7.7.23 uridine competitive with diphosphate, noncompetitive with UDP-N-acetyl-D-glucosamine, activity could be restored by dialysis Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.7.23 diphosphate + UDP-N-acetyl-D-glucosamine Saccharomyces cerevisiae amino sugar metabolism UTP + N-acetyl-alpha-D-glucosamine 1-phosphate
-
 r
2.7.7.23 diphosphate + UDP-N-acetyl-D-glucosamine Neurospora crassa amino sugar metabolism UTP + N-acetyl-alpha-D-glucosamine 1-phosphate
-
 r
2.7.7.23 diphosphate + UDP-N-acetyl-D-glucosamine Saccharomyces cerevisiae involved in synthesis of peptidoglycan and teichoic acid UTP + N-acetyl-alpha-D-glucosamine 1-phosphate
-
 r
2.7.7.23 diphosphate + UDP-N-acetyl-D-glucosamine Neurospora crassa involved in synthesis of peptidoglycan and teichoic acid UTP + N-acetyl-alpha-D-glucosamine 1-phosphate
-
 r

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.23 Neurospora crassa
-
-
-
2.7.7.23 Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.23 diphosphate + UDP-N-acetyl-D-glucosamine
-
 Saccharomyces cerevisiae UTP + N-acetyl-alpha-D-glucosamine 1-phosphate
-
 r
2.7.7.23 diphosphate + UDP-N-acetyl-D-glucosamine
-
 Neurospora crassa UTP + N-acetyl-alpha-D-glucosamine 1-phosphate
-
 r
2.7.7.23 diphosphate + UDP-N-acetyl-D-glucosamine amino sugar metabolism Saccharomyces cerevisiae UTP + N-acetyl-alpha-D-glucosamine 1-phosphate
-
 r
2.7.7.23 diphosphate + UDP-N-acetyl-D-glucosamine amino sugar metabolism Neurospora crassa UTP + N-acetyl-alpha-D-glucosamine 1-phosphate
-
 r
2.7.7.23 diphosphate + UDP-N-acetyl-D-glucosamine involved in synthesis of peptidoglycan and teichoic acid Saccharomyces cerevisiae UTP + N-acetyl-alpha-D-glucosamine 1-phosphate
-
 r
2.7.7.23 diphosphate + UDP-N-acetyl-D-glucosamine involved in synthesis of peptidoglycan and teichoic acid Neurospora crassa UTP + N-acetyl-alpha-D-glucosamine 1-phosphate
-
 r