Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Zhou, J.; Ryan, A.J.; Medh, J.; Mallampalli, R.K.
    Oxidized lipoproteins inhibit surfactant phosphatidylcholine synthesis via calpain-mediated Cleavage of CTP:phosphocholine cytidylyltransferase (2003), J. Biol. Chem., 278, 37032-37040.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.7.15
-
 Rattus norvegicus

Protein Variants

EC Number Protein Variants Comment Organism
2.7.7.15 K238R/K239R/Y240F increased resistance to calpain cleavage, resistance to enzyme degradation by oxidized low density lipoprotein Mus musculus
2.7.7.15 additional information deletion mutant lacking the putative membrane binding domain Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.7.15 oxidized low density lipoprotein 40% inhibition by increase of enzyme degradation; 75% inhibition by increase of enzyme degradation Mus musculus
2.7.7.15 oxidized low density lipoprotein
-
 Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.15 Mus musculus
-
-
-
2.7.7.15 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.7.15
-
 Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.7.15 alveolar cell
-
 Rattus norvegicus
-
2.7.7.15 epithelial cell
-
 Mus musculus
-
2.7.7.15 epithelial cell
-
 Rattus norvegicus
-
2.7.7.15 lung
-
 Mus musculus
-
2.7.7.15 lung
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.15 CTP + choline phosphate
-
 Mus musculus diphosphate + CDPcholine
-
 ?
2.7.7.15 CTP + choline phosphate
-
 Rattus norvegicus diphosphate + CDPcholine
-
 ?