Literature summary extracted from

Boggs, K.P.; Rock, C.O.; Jackowski, S.
Lysophosphatidylcholine and 1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine inhibit the CDP-choline pathway of phosphatidylcholine synthesis at the CTP:phosphocholine cytidylyltransferase step (1995), J. Biol. Chem., 270, 7757-7764.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
2.7.7.15	1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphatidylcholine	ET-18-OCH3, non-hydrolyzable lysophosphatidylcholine analog, competitive with respect to the lipid activator	Mus musculus
2.7.7.15	lysophosphatidylcholine	competitive with respect to the lipid activator, 50% inhibition at 0.025 mM in the presence of phosphatidylcholine/oleic acid	Mus musculus

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.7.7.15	Mus musculus	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
2.7.7.15	macrophage	BAC1.2F5 cell line, SCF-1-dependent clone derived from the BAC1 line which originated from transfection of splenic adherent cells with SV40	Mus musculus	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2.7.7.15	CTP + choline phosphate	-	Mus musculus	diphosphate + CDPcholine	-	?

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Release 2023.1 (January 2023)