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Literature summary extracted from

  • Jamil, H.; Vance, D.E.
    Substrate specificity of CTP:phosphocholine cytidylyltransferase (1991), Biochim. BIophys. Acta, 1086, 335-339.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.7.15 phosphodimethylethanolamine competitive to phosphocholine Rattus norvegicus
2.7.7.15 Phosphoethanolamine competitive to phosphocholine Rattus norvegicus
2.7.7.15 phosphomonomethylethanolamine competitive to phosphocholine Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.7.15 0.17
-
 phosphocholine pH 7, 37°C Rattus norvegicus
2.7.7.15 4
-
 phosphodimethylethanolamine pH 7, 37°C Rattus norvegicus
2.7.7.15 6.9
-
 phosphomonomethylethanolamine pH 7, 37°C Rattus norvegicus
2.7.7.15 69.4
-
 Phosphoethanolamine pH 7, 37°C Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.15 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.7.15
-
 Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.7.15 liver
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.7.7.15 0.35
-
 with phosphoethanolamine as substrate Rattus norvegicus
2.7.7.15 3.45
-
 with phosphomonomethylethanolamine as substrate Rattus norvegicus
2.7.7.15 10.7
-
 with phosphocholine as substrate Rattus norvegicus
2.7.7.15 16.12
-
 with phosphodimethylethanolamine as substrate Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.15 CTP + choline phosphate
-
 Rattus norvegicus diphosphate + CDPcholine
-
 ?
2.7.7.15 CTP + ethanolamine phosphate
-
 Rattus norvegicus diphosphate + CDPethanolamine
-
 ?
2.7.7.15 CTP + phosphodimethylethanolamine
-
 Rattus norvegicus diphosphate + CDPdimethylethanolamine
-
 ?
2.7.7.15 CTP + phosphomonomethylethanolamine
-
 Rattus norvegicus diphosphate + CDPmethylethanolamine
-
 ?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.7.7.15 1
-
 phosphodimethylethanolamine pH 7, 37°C Rattus norvegicus
2.7.7.15 7.8
-
 phosphomonomethylethanolamine pH 7, 37°C Rattus norvegicus
2.7.7.15 16.7
-
 Phosphoethanolamine pH 7, 37°C Rattus norvegicus