Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Gasull, T.; Sarri, E.; DeGregorio-Rocasolano, N.; Trullas, R.
    NMDA receptor overactivation inhibits phospholipid synthesis by decreasing choline-ethanolamine phosphotransferase activity (2003), J. Neurosci., 23, 4100-4107.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
2.7.8.1 medicine exposure of cortical neurons to neurotoxic concentrations of N-methyl-D-aspartate strongly reduces enzymic activity Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.7.14 additional information overactivation of the NMDA receptor in neurons inhibits the enzyme, membrane damage by NMDA receptor is preceeded by inhibition of phospholipid synthesis Rattus norvegicus
2.7.8.1 N-Methyl-D-aspartate strong Rattus norvegicus
2.7.8.2 N-Methyl-D-aspartate strong Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.7.14 membrane
-
 Rattus norvegicus 16020
-
2.7.7.14 microsome
-
 Rattus norvegicus
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.7.14 Mg2+
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.7.14 CTP + ethanolamine phosphate Rattus norvegicus rate-regulatory enzyme of phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway diphosphate + CDP-ethanolamine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.14 Rattus norvegicus
-
 Sprague-Dawley rats
-
2.7.8.1 Rattus norvegicus
-
 fetus, dual-specificity enzyme, activity of EC 2.7.8.1 and EC 2.7.8.2
-
2.7.8.2 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.7.14 brain
-
 Rattus norvegicus
-
2.7.7.14 brain cortex
-
 Rattus norvegicus
-
2.7.7.14 cell culture primary from brain cortical neurons Rattus norvegicus
-
2.7.7.14 additional information overactivation of the NMDA receptor, i.e. N-methyl-D-aspartic acid receptor, in neurons by toxic concentrations inhibits the enzyme, membrane damage by NMDA receptor is preceeded by inhibition of phospholipid synthesis Rattus norvegicus
-
2.7.7.14 neuron cortical Rattus norvegicus
-
2.7.8.1 brain of fetus Rattus norvegicus
-
2.7.8.2 brain fetal Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.14 CTP + ethanolamine phosphate
-
 Rattus norvegicus diphosphate + CDP-ethanolamine
-
 ?
2.7.7.14 CTP + ethanolamine phosphate rate-regulatory enzyme of phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway Rattus norvegicus diphosphate + CDP-ethanolamine
-
 ?
2.7.8.2 CDP-choline + 1,2-diacylglycerol
-
 Rattus norvegicus CMP + a phosphatidylcholine
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.7.14 37
-
 assay at Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.7.14 8.5
-
 assay at Rattus norvegicus