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Literature summary extracted from

  • Vermeulen, P.S.; Tijburg, L.B.M.; Geelen, M.J.H.; van Golde, L.M.G.
    Immunological characterization, lipid dependence, and subcellular localization of CTP:phosphoethanolamine cytidylyltransferase purified from rat liver. Comparison with CTP:phosphocholine cytidylyltransferase (1993), J. Biol. Chem., 268, 7458-7464.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.7.14 phosphatidylglycerol slightly stimulating Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.7.14 iodoacetamide
-
 Rattus norvegicus
2.7.7.14 NEM
-
 Rattus norvegicus
2.7.7.14 oleate
-
 Rattus norvegicus
2.7.7.14 PCMB
-
 Rattus norvegicus
2.7.7.14 Sphingosine/phosphatidylcholine vesicles inhibit cytosolic and purified enzyme Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.7.14 cytosol postmicrosomal supernatant Rattus norvegicus 5829
-
2.7.7.14 additional information approximately 50% of the total activity is in the supernatant, the remainder being distributed among subcellular localizations Rattus norvegicus
-
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.7.14 49600
-
 x * 49600, SDS-PAGE Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.7.14 CTP + ethanolamine phosphate Rattus norvegicus rate-regulatory enzyme of phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway diphosphate + CDP-ethanolamine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.14 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.7.14 1430fold to homogeneity Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.7.14 hepatocyte
-
 Rattus norvegicus
-
2.7.7.14 liver
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.7.7.14 6.505
-
-
 Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.14 CTP + ethanolamine phosphate
-
 Rattus norvegicus diphosphate + CDP-ethanolamine
-
 ?
2.7.7.14 CTP + ethanolamine phosphate rate-regulatory enzyme of phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway Rattus norvegicus diphosphate + CDP-ethanolamine
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.7.14 ? x * 49600, SDS-PAGE Rattus norvegicus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.7.14 37
-
 assay at Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.7.14 7.8
-
 assay at Rattus norvegicus

pI Value

EC Number Organism Comment pI Value Maximum pI Value
2.7.7.14 Rattus norvegicus
-
-
 6.5