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Literature summary extracted from

  • Davit-Spraul, A.; Pourci, M.L.; Ng, K.H.; Soni, T.; Lemonnier, A.
    Regulatory effects of galactose on galactose-1-phosphate uridyltransferase activity on human hepatoblastoma HepG2 cells (1994), FEBS Lett., 354, 232-236.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.7.12 D-galactose galactose growth medium induces enzyme activity, not expression, and increases Vmax by about 50% compared to glucose medium Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.7.12 alpha-D-galactose 1-phosphate substrate inhibition at concentrations above 1.5 mM Homo sapiens
2.7.7.12 UDP-glucose substrate inhibition at concentrations above 0.5 mM Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.7.12 0.09
-
 alpha-D-galactose 1-phosphate galactose grown cells, pH 8.2 Homo sapiens
2.7.7.12 0.1
-
 alpha-D-galactose 1-phosphate glucose grown cells, pH 8.2 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.12 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.7.12 Hep-G2 cell hepatoblastoma cell line, grown on glucose or galactose Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.7.7.12 0.008
-
 HepG2 cells grown on glucose medium Homo sapiens
2.7.7.12 0.012
-
 HepG2 cells grown on galactose medium Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.12 UDP-glucose + alpha-D-galactose 1-phosphate
-
 Homo sapiens alpha-D-glucose 1-phosphate + UDP-galactose
-
 r

Synonyms

EC Number Synonyms Comment Organism
2.7.7.12 GALT
-
 Homo sapiens

pI Value

EC Number Organism Comment pI Value Maximum pI Value
2.7.7.12 Homo sapiens different isozymic pattern in cells grown in glucose, galactose or inosine media
-
 additional information