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Literature summary extracted from

  • Zhang, X.; Kurnasov, O.V.; Karthikeyan, S.; Grishin, N.V.; Osterman, A.L.; Zhang, H.
    Structural characterization of a human cytosolic NMN/NaMN adenylyltransferase and implication in human NAD biosynthesis (2003), J. Biol. Chem., 278, 13503-13511.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.7.1 overexpression in Escherichia coli of PNAT-3 with a His-tag Homo sapiens

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.7.7.1 hanging drop vapor diffusion method, 20 mg/ml protein mixed with an equal volume of reservoir solution containing 100 mM sodium cacodylate, pH 6-7, 200 mM Li2SO4 and 20-25% polyethylene glycol 400 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.7.1 cytoplasm PNAT-3 Homo sapiens 5737
-
2.7.7.1 mitochondrion PNAT-3 Homo sapiens 5739
-
2.7.7.1 nucleus PNAT-1 and PNAT-2 Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.7.1 ATP + nicotinamide ribonucleotide Homo sapiens
-
 diphosphate + NAD+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.1 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.7.1 kidney PNAT-3 weak Homo sapiens
-
2.7.7.1 lung PNAT-3 Homo sapiens
-
2.7.7.1 placenta PNAT-3 weak Homo sapiens
-
2.7.7.1 spleen PNAT-3 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.1 ATP + nicotinamide ribonucleotide
-
 Homo sapiens diphosphate + NAD+
-
 ?
2.7.7.1 ATP + nicotinamide ribonucleotide i.e. NMN or nicotinamide mononucleotide Homo sapiens diphosphate + NAD+
-
 r
2.7.7.1 ATP + nicotinate ribonucleotide i.e. nicotinate mononucleotide Homo sapiens diphosphate + nicotinic acid-adenine dinucleotide
-
 r