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Literature summary extracted from

  • Jones, G.H.
    Activation of ATP:GTP 3-pyrophosphotransferase (guanosine pentaphosphate synthetase) in Streptomyces antibioticus (1994), J. Bacteriol., 176, 1482-1487.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.6.5 methanol maximal stimulation of GPSI by 20% v/v Streptomyces antibioticus
2.7.6.5 additional information no activation by ribosomes Streptomyces antibioticus
2.7.6.5 additional information GPS I can be activated by incubation with crude mycelial extract, activation is partially inhibited by the inclusion of trypsin inhibitor in reaction mixture Streptomyces antibioticus
2.7.6.5 mRNA synthetic, e.g. poly(U), stimulates, level of stimulation is greater in presence of RNA and poly(U) together than with either RNA alone, no activation by ribosomes Streptomyces antibioticus
2.7.6.5 tRNA uncharged or charged, stimulation, level of stimulation is greater in presence of RNA and poly(U) together than with either RNA alone Streptomyces antibioticus
2.7.6.5 Trypsin incubation with low levels of trypsin activates Streptomyces antibioticus

Organism

EC Number Organism UniProt Comment Textmining
2.7.6.5 Streptomyces antibioticus
-
2 enzyme forms: GPS I
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.6.5 mycelium
-
Streptomyces antibioticus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.6.5 ATP + GTP
-
Streptomyces antibioticus AMP + guanosine 3'-diphosphate 5'-triphosphate
-
?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.6.5 37
-
assay at Streptomyces antibioticus