EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.7.6.1 | 1,2,3-trihydroxy-4-cyclopentanemethanol-6-phosphate | mixed-type inhibition with respect to D-ribose 5-phosphate and no inhibition against ATP | Bacillus subtilis | |
2.7.6.1 | 1,2,3-trihydroxy-4-cyclopentanemethanol-6-phosphate | at pH 7.5, competitive inhibition with respect to D-ribose 5-phosphate and noncompetitive inhibition with respect to ATP | Homo sapiens | |
2.7.6.1 | 1,2,3-trihydroxy-4-cyclopentanemethanol-6-phosphate | at pH 7.5, competitive inhibition with respect to D-ribose 5-phosphate and noncompetitive inhibition with respect to ATP | Salmonella enterica subsp. enterica serovar Typhimurium | |
2.7.6.1 | 1,4,5-trihydroxy-3-cyclopent-2-enemethanol-6-phosphate | partial noncompetitive inhibition with respect to D-ribose 5-phosphate and no inhibition with respect to ATP | Homo sapiens | |
2.7.6.1 | 1,4,5-trihydroxy-3-cyclopent-2-enemethanol-6-phosphate | partial mixed-type inhibition with respect to D-ribose 5-phosphate and ATP | Salmonella enterica subsp. enterica serovar Typhimurium |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.7.6.1 | 0.135 | - |
D-ribose 5-phosphate | pH 8.0, 37ºC | Homo sapiens | |
2.7.6.1 | 0.14 | - |
ATP | pH 8.0, 37ºC | Homo sapiens | |
2.7.6.1 | 0.193 | - |
ATP | pH 8.0, 37ºC | Salmonella enterica subsp. enterica serovar Typhimurium | |
2.7.6.1 | 0.298 | - |
D-ribose 5-phosphate | pH 8.0, 37ºC | Salmonella enterica subsp. enterica serovar Typhimurium | |
2.7.6.1 | 0.791 | - |
D-ribose 5-phosphate | pH 8.0, 37ºC | Bacillus subtilis | |
2.7.6.1 | 1.127 | - |
ATP | pH 8.0, 37ºC | Bacillus subtilis |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.6.1 | ATP + D-ribose 5-phosphate | Salmonella enterica subsp. enterica serovar Typhimurium | the product phosphoribosyldiphosphate is required for the biosynthesis of purine, pyrimidine and pyridine nucleotides, L-histidine and L-tryptophan | AMP + 5-phospho-alpha-D-ribose 1-diphosphate | - |
r | |
2.7.6.1 | ATP + D-ribose 5-phosphate | Bacillus subtilis | the product phosphoribosyldiphosphate is required for the biosynthesis of purine, pyrimidine and pyridine nucleotides, L-histidine and L-tryptophan | AMP + 5-phospho-alpha-D-ribose 1-diphosphate | - |
r | |
2.7.6.1 | ATP + D-ribose 5-phosphate | Homo sapiens | the product phosphoribosyldiphosphate is required for the biosynthesis of purine, pyrimidine and pyridine nucleotides, L-histidine and L-tryptophan | AMP + 5-phospho-alpha-D-ribose 1-diphosphate | - |
r |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.7.6.1 | Bacillus subtilis | - |
- |
- |
2.7.6.1 | Homo sapiens | - |
- |
- |
2.7.6.1 | Salmonella enterica subsp. enterica serovar Typhimurium | - |
- |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.6.1 | ATP + 1,2,3-trihydroxy-4-cyclopentanemethanol-6-phosphate | very poor substrate | Salmonella enterica subsp. enterica serovar Typhimurium | ? | - |
? | |
2.7.6.1 | ATP + 1,2,3-trihydroxy-4-cyclopentanemethanol-6-phosphate | very poor substrate | Homo sapiens | ? | - |
? | |
2.7.6.1 | ATP + 1,4,5-trihydroxy-3-cyclopent-2-enemethanol-6-phosphate | very poor substrate, better than 1,2,3-trihydroxy-4-cyclopentanemethanol-6-phosphate | Salmonella enterica subsp. enterica serovar Typhimurium | ? | - |
? | |
2.7.6.1 | ATP + 1,4,5-trihydroxy-3-cyclopent-2-enemethanol-6-phosphate | very poor substrate, better than 1,2,3-trihydroxy-4-cyclopentanemethanol-6-phosphate | Homo sapiens | ? | - |
? | |
2.7.6.1 | ATP + D-ribose 5-phosphate | - |
Salmonella enterica subsp. enterica serovar Typhimurium | AMP + 5-phospho-alpha-D-ribose 1-diphosphate | - |
r | |
2.7.6.1 | ATP + D-ribose 5-phosphate | - |
Bacillus subtilis | AMP + 5-phospho-alpha-D-ribose 1-diphosphate | - |
r | |
2.7.6.1 | ATP + D-ribose 5-phosphate | - |
Homo sapiens | AMP + 5-phospho-alpha-D-ribose 1-diphosphate | - |
r | |
2.7.6.1 | ATP + D-ribose 5-phosphate | the product phosphoribosyldiphosphate is required for the biosynthesis of purine, pyrimidine and pyridine nucleotides, L-histidine and L-tryptophan | Salmonella enterica subsp. enterica serovar Typhimurium | AMP + 5-phospho-alpha-D-ribose 1-diphosphate | - |
r | |
2.7.6.1 | ATP + D-ribose 5-phosphate | the product phosphoribosyldiphosphate is required for the biosynthesis of purine, pyrimidine and pyridine nucleotides, L-histidine and L-tryptophan | Bacillus subtilis | AMP + 5-phospho-alpha-D-ribose 1-diphosphate | - |
r | |
2.7.6.1 | ATP + D-ribose 5-phosphate | the product phosphoribosyldiphosphate is required for the biosynthesis of purine, pyrimidine and pyridine nucleotides, L-histidine and L-tryptophan | Homo sapiens | AMP + 5-phospho-alpha-D-ribose 1-diphosphate | - |
r |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
2.7.6.1 | 37 | - |
assay at | Salmonella enterica subsp. enterica serovar Typhimurium |
2.7.6.1 | 37 | - |
assay at | Homo sapiens |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
2.7.6.1 | 7 | - |
- |
Salmonella enterica subsp. enterica serovar Typhimurium |
2.7.6.1 | 7 | - |
- |
Homo sapiens |